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18-(4-iodophenyl)octadecylphosphocholine (NM 404)

has antineoplastic activity; structure in first source

Also Known As:

NM 404; NM-404; NM404 cpd

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Choline: 6256
        Phosphorylcholine: 752
        18-(4-iodophenyl)octadecylphosphocholine: 1
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - Choline: 6256
      - Phosphorylcholine: 752
        18-(4-iodophenyl)octadecylphosphocholine: 1

Experts

1.	Counsell, Raymond E: 1 article (04/2006)
2.	Gross, Milton D: 1 article (04/2006)
3.	Longino, Marc A: 1 article (04/2006)
4.	Pinchuk, Anatoly N: 1 article (04/2006)
5.	Rampy, Mark A: 1 article (04/2006)
6.	Skinner, R W Scott: 1 article (04/2006)
7.	Weichert, Jamey P: 1 article (04/2006)

Related Diseases

1.	Neoplasms (Cancer) 04/06/2006 - "On the basis of imaging and tissue distribution studies in several rodent tumor models, the C18 analogue, NM-404, was chosen for follow-up evaluation in human lung cancer patients. " 04/06/2006 - "A direct comparison between NM-404 and its predecessor, NM-324, in human PC-3 tumor bearing immune-compromised mice revealed a dramatic enhancement in both tumor uptake and total body elimination of NM-404 relative to NM-324. " 04/06/2006 - "These results strongly suggest that extension of the human trials to include other cancers is warranted, especially when NM-404 is radiolabeled with iodine-124, a new commercially available positron-emitting isotope. "
2.	Lung Neoplasms (Lung Cancer) 04/06/2006 - "On the basis of imaging and tissue distribution studies in several rodent tumor models, the C18 analogue, NM-404, was chosen for follow-up evaluation in human lung cancer patients. "

Related Drugs and Biologics

1.	Isotopes
2.	Iodine-124
3.	NM 324