HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

6- (1- hydroxyimino- 4- methylpentyl)- 5,8- dimethoxy- 1,4- naphthoquinone

has antineoplastic activity; structure in first source

Also Known As:

DMNQ S-52

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        6-(1-hydroxyimino-4-methylpentyl)-5,8-dimethoxy-1,4-naphthoquinone: 1
- Quinones: 434
  - Naphthoquinones: 418
    - 6-(1-hydroxyimino-4-methylpentyl)-5,8-dimethoxy-1,4-naphthoquinone: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - 6-(1-hydroxyimino-4-methylpentyl)-5,8-dimethoxy-1,4-naphthoquinone: 1

Experts

1.	Bae, Yong Soo: 1 article (02/2006)
2.	Kang, Kyung-Sun: 1 article (02/2006)
3.	Kim, Hyung-Min: 1 article (02/2006)
4.	Kim, Sung Hoon: 1 article (02/2006)
5.	Koizumi, Keiichi: 1 article (02/2006)
6.	Lee, Soo Jin: 1 article (02/2006)
7.	Saiki, Ikuo: 1 article (02/2006)
8.	Sakurai, Hiroaki: 1 article (02/2006)
9.	Song, Gyu Yong: 1 article (02/2006)
10.	Surh, Young-Joon: 1 article (02/2006)

Related Diseases

1.	Neoplasms (Cancer) 02/20/2006 - "In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. " 02/20/2006 - "Taken together, these findings demonstrate that DMNQ S-52 may exhibit anti-tumor activity by inducing apoptosis via caspases and mitogen activated protein (MAP) kinase-dependent pathways." 02/20/2006 - "Immunohistochemical analysis revealed the decreased tumor cell proliferation and increased tumor cell apoptosis in DMNQ S-52 treated tumor sections using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) and proliferation cell nuclear antigen (PCNA). "
2.	Lewis Lung Carcinoma 02/20/2006 - "DMNQ S-52 exerted cytotoxicity against Lewis lung carcinoma (LLC) cells (IC50=12.3 microM). " 02/20/2006 - "MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells."

Related Drugs and Biologics

1.	Nuclear Antigens (Extractable Nuclear Antigens)
2.	Caspases
3.	Proliferating Cell Nuclear Antigen (PCNA)
4.	Proteins (Proteins, Gene)
5.	Phosphotransferases (Kinase)
6.	Mitogens
7.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
8.	deoxyuridine triphosphate