AD2765

a thiourea derivative of sphingomyelin

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Niemann-Pick Diseases (Niemann Pick Disease) 11/01/2005 - "Thus, AD2765 might be used to manipulate sphingomyelin metabolism in various ways, potentially to reduce substrate accumulation in cells from types A and B Niemann-Pick disease patients, and/or to affect the growth of human cancer cells."
2.	Neoplasms (Cancer) 11/01/2005 - "Thus, AD2765 might be used to manipulate sphingomyelin metabolism in various ways, potentially to reduce substrate accumulation in cells from types A and B Niemann-Pick disease patients, and/or to affect the growth of human cancer cells." 11/01/2005 - "The overall effect of AD2765 on sphingomyelin metabolism was concentration-dependent, and treatment of normal human skin fibroblasts or cancer cells with this compound at concentrations > 10 microM led to an increase in cellular ceramide and cell death. "