VAF347

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2 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: Anti-Inflammatory Agents, Non-Steroidal

Also Known As:

(4-(3-chlorophenyl)pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)amine

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Pyrimidines: 269

VAF347: 2

Related Diseases

1.	Pneumonia (Pneumonitis) 08/15/2008 - "VAF347 is a low-molecular-weight compound that inhibits allergic lung inflammation in vivo" 03/15/2006 - "The biological effects in vivo are most likely mediated by the immunoregulatory role of VAF347 on DCs because allergic lung inflammation was also inhibited in B-cell-deficient mice" 08/15/2008 - "Functional AhR is responsible for the biologic activity of VAF347 because (1) other AhR agonists display an identical activity profile in vitro, (2) gene silencing of wild-type AhR expression or forced overexpression of a trans-dominant negative AhR ablates VAF347 activity to inhibit cytokine induced IL-6 expression in a human monocytic cell line, and (3) AhR-deficient mice are resistant to the compound's ability to block allergic lung inflammation in vivo" 03/15/2006 - "In a mouse model of antigen-induced eosinophilic inflammation, VAF347 blocked lung eosinophilia, mucus hyperplasia, and serum IgE levels, representing the hallmarks of allergic lung inflammation" Get all the results and reference details, order at left...
2.	Inflammation 03/15/2006 - "In a mouse model of antigen-induced eosinophilic inflammation, VAF347 blocked lung eosinophilia, mucus hyperplasia, and serum IgE levels, representing the hallmarks of allergic lung inflammation" Get all the results and reference details, order at left...
3.	Hyperplasia 03/15/2006 - "In a mouse model of antigen-induced eosinophilic inflammation, VAF347 blocked lung eosinophilia, mucus hyperplasia, and serum IgE levels, representing the hallmarks of allergic lung inflammation" Get all the results and reference details, order at left...
4.	Eosinophilia 03/15/2006 - "In a mouse model of antigen-induced eosinophilic inflammation, VAF347 blocked lung eosinophilia, mucus hyperplasia, and serum IgE levels, representing the hallmarks of allergic lung inflammation" Get all the results and reference details, order at left...
4 Diseases and 2 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Immunoglobulin E (IgE)
3.	Antigens
3 Drugs and Important Bio-Agents and 2 more articles analyzed in the Research Interface, order at left...

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