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G7-18NATE

a growth factor receptor-bound protein-7 inhibitor

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - G7-18NATE: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - G7-18NATE: 5

Experts

1.	Wilce, Jacqueline A: 3 articles (02/2017 - 12/2010)
2.	Aguilar, Marie-Isabel: 2 articles (02/2017 - 12/2010)
3.	Del Borgo, Mark P: 2 articles (02/2017 - 01/2012)
4.	Wilce, Matthew C J: 2 articles (01/2012 - 12/2010)
5.	Brandt, Rebecca: 1 article (02/2017)
6.	Kulkarni, Ketav: 1 article (02/2017)
7.	Watson, Gabrielle M: 1 article (02/2017)
8.	Ambaye, Nigus D: 1 article (01/2012)
9.	Gunzburg, Menachem J: 1 article (01/2012)
10.	Krag, David N: 1 article (01/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "G7-18NATE effectively inhibits the interaction of Grb7 with ErbB3 and focal adhesion kinase in cell lysates and, with the addition of a cell permeability sequence, inhibits the growth and migration of a number of breast cancer cell lines. " 05/21/2007 - "In this study, we have shown that both Penetratin- and Tat-conjugated G7-18NATE peptides are able to inhibit the proliferation of SK-BR-3, ZR-75-30, MDA-MB-361 and MDA-MB-231 breast cancer cells. "
2.	Neoplasms (Cancer) 12/01/2010 - "Its overexpression in several cancer types has implicated it in cancer progression and led to the development of the G7-18NATE cyclic peptide inhibitor. " 12/01/2010 - "The structure of the G7-18NATE peptide in complex with its target will facilitate the rational development of Grb7-targeted cancer therapeutics." 01/01/2012 - "The G7-18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein, implicated in the progression of several cancer types, via interactions with its SH2 domain. " 02/28/2017 - "Here, we performed a detailed comparison of cellular uptake by Penetratin (P16) and the truncated Penetratin peptide (P7), including their ability to deliver G7-18NATE, a cyclic peptide targeting the cytosolic cancer target Grb7-adapter protein into cells. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2007 - "It has been shown that G7-18NATE is able to compete with natural ligands for the Grb7 SH2 phosphotyrosine binding site, and to attenuate cell migration in a pancreatic cancer cell line. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	penetratin
3.	Cyclic Peptides
4.	Proteins (Proteins, Gene)
5.	Focal Adhesion Protein-Tyrosine Kinases
6.	GRB7 Adaptor Protein
7.	Phosphotyrosine
8.	Ligands

Related Therapies and Procedures

1.	Therapeutics