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mitraphylline

isolated from Uncaria tomentosa

Also Known As:

methyl (19alpha)-19-methyl-2-oxoformosanan-16-carboxylate

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Oxindoles: 118
      - mitraphylline: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Oxindoles: 118
        mitraphylline: 4
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Oxindoles: 118
        mitraphylline: 4

Experts

1.	An, Seong Soo A: 1 article (12/2020)
2.	Tan, Mario A: 1 article (12/2020)
3.	Alban-Castillo, J: 1 article (10/2012)
4.	Auberger, P: 1 article (10/2012)
5.	Bourdy, G: 1 article (10/2012)
6.	Deharo, E: 1 article (10/2012)
7.	Doroteo-Ortega, V H: 1 article (10/2012)
8.	González-Aspajo, G: 1 article (10/2012)
9.	Robert, G: 1 article (10/2012)
10.	Rojas-Duran, R: 1 article (10/2012)

Related Diseases

1.	Neuroblastoma 04/01/2007 - "This action suggests that mitraphylline is a new and promising agent in the treatment of human neuroblastoma and glioma." 04/01/2007 - "Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines." 12/01/2020 - "Neuroprotective potential of the oxindole alkaloids isomitraphylline and mitraphylline in human neuroblastoma SH-SY5Y cells."
2.	Ewing Sarcoma (Sarcoma, Ewing) 02/01/2010 - "Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines."
3.	Sarcoma (Soft Tissue Sarcoma) 02/01/2010 - "This action suggests that the pentacyclic oxindole alkaloid mitraphylline might be a new promising agent in the treatment of both human sarcoma and breast cancer."
4.	Inflammation (Inflammations) 10/11/2012 - "For the first time mitraphylline was tested in vivo against a large range of cytokines that play a crucial role in inflammation. "
5.	Glioma (Gliomas) 04/01/2007 - "This action suggests that mitraphylline is a new and promising agent in the treatment of human neuroblastoma and glioma." 04/01/2007 - "Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines."

Related Drugs and Biologics

1.	Oxindoles
2.	Cytokines
3.	Amyloid (Amyloid Fibrils)
4.	isomitraphylline