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3',4'-dimethoxyflavone

Also Known As:

3',4'-DMF

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        3',4'-dimethoxyflavone: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        3',4'-dimethoxyflavone: 4

Experts

1.	Walle, Thomas: 2 articles (08/2006 - 10/2005)
2.	Chen, Hung-Sheng: 1 article (01/2012)
3.	Chiang, Po-Hui: 1 article (01/2012)
4.	Kao, Mi-Chun: 1 article (01/2012)
5.	Shieh, Tsung-Hua: 1 article (01/2012)
6.	Tsai, Cheng-Fang: 1 article (01/2012)
7.	Tsai, Eing-Mei: 1 article (01/2012)
8.	Wang, Yu-Chih: 1 article (01/2012)
9.	Tsuji, Petra A: 1 article (08/2006)
10.	Wen, Xia: 1 article (10/2005)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2006 - "In this study, we used benzo[a]pyrene (BaP) as the classic PAH compound and BEAS-2B cells, a model of normal human bronchial epithelial cells, to investigate whether 5,7-dimethoxyflavone (5,7-DMF) and 3',4'-DMF compared with resveratrol (RV) have chemopreventive properties in this cancer. "
2.	Necrosis 01/01/2012 - "Necrosis was significantly increased in HO23 cells after BBP treatment, and 3',4'-DMF, AhR siRNA or CYP1B1 siRNA knockdown blocked this phenomenon. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/01/2005 - "benzo[a]pyrene (BaP), induced DNA binding and their inhibition by the dietary polyphenol 5,7-dimethoxyflavone (DMF), compared with 3',4'-dimethoxyflavone (3',4'-DMF) and resveratrol, were investigated in the human oral epithelial squamous cell carcinoma (SCC)-9 cells. "
4.	Breast Neoplasms (Breast Cancer) 12/01/2000 - "Gel mobility shift assays using rat liver cytosol and breast cancer cell nuclear extracts showed that 3',4'-DMF alone did not transform the AhR to its nuclear binding form, but inhibited TCDD-induced AhR transformation in rat liver cytosol and blocked TCDD-induced formation of the nuclear AhR complex in MCF-7 and T47D cells. " 12/01/2000 - "3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells." 12/01/2000 - "TCDD also inhibited estrogen-induced transactivation in MCF-7 cells, and this response was also blocked by 3',4'-DMF, confirming the AhR antagonist activity of this compound in breast cancer cells."

Related Drugs and Biologics

1.	Benzo(a)pyrene
2.	Resveratrol
3.	5,7-dimethoxyflavone
4.	Polyphenols
5.	Small Interfering RNA (siRNA)
6.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
7.	Estrogens (Estrogen)
8.	DNA (Deoxyribonucleic Acid)
9.	Polychlorinated Dibenzodioxins (TCDD)
10.	4-boronic acid benzophenone