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pegylated 17-hydroxywortmannin

structure in first source

Also Known As:

PWT 458; PWT-458; PWT458

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Yilun: 1 article (01/2016)
2.	Dendy, Meaghan: 1 article (01/2016)
3.	Gruvberger-Saal, Sofia K: 1 article (01/2016)
4.	Hibshoosh, Hanina: 1 article (01/2016)
5.	Horlings, Hugo M: 1 article (01/2016)
6.	Isola, Jorma: 1 article (01/2016)
7.	Jumppanen, Mervi: 1 article (01/2016)
8.	Lau, Ying-Ka Ingar: 1 article (01/2016)
9.	Maurer, Matthew: 1 article (01/2016)
10.	Memeo, Lorenzo: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2005 - "Here we show that a single intravenous injection of PWT-458 rapidly inhibited PI3K signaling, as measured by a complete loss of AKT (Ser-473) phosphorylation in xenograft tumors grown in nude mice. " 05/01/2005 - "PWT-458 augmented anticancer efficacy of a suboptimal dose of paclitaxel against A549 and U87MG tumors. " 05/01/2005 - "PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors." 01/01/2016 - "Combination treatment of BLBC cell lines with the EGFR-inhibitor gefitinib plus the PI3K pathway inhibitor LY294002 was synergistic, and correspondingly, in an in vivo BLBC xenograft mouse model, gefitinib plus PI3K-inhibitor PWT-458 was more effective than either monotherapy and caused tumor regression. "
2.	Glioma (Gliomas) 05/01/2005 - "Following a daily X5 dosing regimen, PWT-458 demonstrated single-agent antitumor activity in nude mouse xenograft models of U87MG glioma, nonsmall cell lung cancer (NSCLC) A549, and renal cell carcinoma (RCC) A498. "
3.	Renal Cell Carcinoma (Grawitz Tumor) 05/01/2005 - "Following a daily X5 dosing regimen, PWT-458 demonstrated single-agent antitumor activity in nude mouse xenograft models of U87MG glioma, nonsmall cell lung cancer (NSCLC) A549, and renal cell carcinoma (RCC) A498. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/01/2005 - "Following a daily X5 dosing regimen, PWT-458 demonstrated single-agent antitumor activity in nude mouse xenograft models of U87MG glioma, nonsmall cell lung cancer (NSCLC) A549, and renal cell carcinoma (RCC) A498. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
3.	Antineoplastic Agents (Antineoplastics)
4.	Gefitinib (Iressa)
5.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one

Related Therapies and Procedures

1.	Intravenous Injections