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PD168393

epidermal growth factor receptor inhibitor

Networked: 11 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - PD168393: 11

Experts

1.	Chen, Jia-Liang: 1 article (01/2019)
2.	Ding, Hong-Lu: 1 article (01/2019)
3.	Li, Wen-Biao: 1 article (01/2019)
4.	Liu, Bo-Long: 1 article (01/2019)
5.	Liu, Xian-Guo: 1 article (01/2019)
6.	Su, Min-Zhi: 1 article (01/2019)
7.	Xie, Jun-Cong: 1 article (01/2019)
8.	Xu, Yuan-Cheng: 1 article (01/2019)
9.	Yang, Fei: 1 article (01/2019)
10.	Zhan, Hai-Lun: 1 article (01/2019)

Related Diseases

1.	Gliosis 04/05/2014 - "The specific EGFR inhibitor PD168393 can ameliorate excessive reactive astrogliosis and facilitate a more favorable environment for axonal regeneration after SCI. As such, EGFR inhibitor may be a promising therapeutic intervention in CNS injury." 04/05/2014 - "Moreover, local administration of PD168393 in the injured area suppressed CSPGs production and glial scar formation, and resulted in reduced demyelination and neuronal loss, which correlated with remarkable hindlimb motor function and bladder improvement in SCI rats. " 04/05/2014 - "EGFR phosphorylation was found to parallel astrocyte activation, and EGFR inhibitor PD168393 potently inhibited scratch-induced reactive astrogliosis and proinflammatory cytokine/mediator secretion of reactive astrocytes in vitro. "
2.	Demyelinating Diseases (Demyelinating Disease) 04/05/2014 - "Moreover, local administration of PD168393 in the injured area suppressed CSPGs production and glial scar formation, and resulted in reduced demyelination and neuronal loss, which correlated with remarkable hindlimb motor function and bladder improvement in SCI rats. "
3.	Sepsis (Septicemia) 11/03/2015 - "To study the effect of EGFR activation on the generation of TNF-α and the occurrence of cardiac dysfuncetion during sepsis, PD168393 and erlotinib (both are EGFR inhibitors) were applied to decreased the production of TNF-α and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes. "
4.	Optic Nerve Injuries 03/10/2011 - "Small molecule EGFR inhibitors such as AG1478 and PD168393 promote CNS axon growth after optic nerve transection despite the presence of inhibitory molecules in the environment of the regenerating axon. "
5.	Neurofibrosarcoma (MPNST) 03/01/2012 - "The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells." 03/01/2012 - "PD168393 induced a cytostatic but not a cytotoxic response in MPNST cells that was accompanied by suppression of Akt and mTOR activation and increased autophagic activity. " 03/01/2012 - "We assessed the effects of the pan erbB inhibitor PD168393 on MPNST cell survival, caspase activation, and autophagy. "

Related Drugs and Biologics

1.	Erlotinib Hydrochloride (CP 358,774)
2.	Androgens
3.	ErbB Receptors (EGF Receptor)
4.	Calcium-Calmodulin-Dependent Protein Kinase Type 4
5.	Cytostatic Agents
6.	Caspases
7.	src-Family Kinases
8.	Paclitaxel (Taxol)
9.	Cytokines
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Catheters