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BIBF 1000

directly induced apoptosis in t(4;14)-positive cell lines as well as in CD138+ marrow cells from patients with t(4;14) myeloma

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - BIBF 1000: 2

Experts

1.	Colbatzky, Florian: 1 article (07/2009)
2.	Handschuh, Sandra: 1 article (07/2009)
3.	Heckel, Armin: 1 article (07/2009)
4.	Hilberg, Frank: 1 article (07/2009)
5.	Kley, Jörg: 1 article (07/2009)
6.	Lehmann-Lintz, Thorsten: 1 article (07/2009)
7.	Lotz, Ralf: 1 article (07/2009)
8.	Roth, Gerald J: 1 article (07/2009)
9.	Tontsch-Grunt, Ulrike: 1 article (07/2009)
10.	Walter, Rainer: 1 article (07/2009)

Related Diseases

1.	Idiopathic Pulmonary Fibrosis 05/01/2007 - "BIBF 1000, or related small molecules with a similar kinase inhibition profile, may represent a novel therapeutic approach for the treatment of idiopathic pulmonary fibrosis."
2.	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/01/2007 - "BIBF 1000 is a small molecule inhibitor targeting the receptor kinases of platelet-derived growth factor (PDGF), basic fibroblast growth factor and vascular endothelial growth factor, which have known roles in the pathogenesis of pulmonary fibrosis. "
3.	Neoplasms (Cancer) 07/23/2009 - "Compounds 2 (BIBF 1000) and 3 (BIBF 1120) are orally available and display encouraging efficacy in in vivo tumor models while being well tolerated. "
4.	Fibrosis (Cirrhosis) 05/01/2007 - "Treatment of rats with BIBF 1000 resulted in the attenuation of fibrosis as assessed by the reduction of collagen deposition and the inhibition of pro-fibrotic gene expression. " 05/01/2007 - "The anti-fibrotic potential of BIBF 1000 was determined in a rat model of bleomycin-induced lung fibrosis and in an ex vivo fibroblast differentiation assay. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3.	Platelet-Derived Growth Factor
4.	Phosphotransferases (Kinase)
5.	Collagen
6.	Bleomycin (Blenoxane)
7.	nintedanib