epoxyquinone A

antineoplastic; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Lymphoma (Lymphomas) 09/08/2006 - "In this study, we show that two synthetic epoxyquinoids, jesterone dimer (JD) and epoxyquinone A monomer (EqM), are equally effective at inhibiting the growth of two human lymphoma cell lines that have constitutively nuclear REL (human c-Rel) DNA-binding complexes, but either express (SUDHL-4 cells) or do not express (RC-K8 cells) the NF-kappaB inhibitor IkappaBalpha. "
2.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 09/08/2006 - "The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line."
3.	Neoplasms (Cancer) 02/28/2006 - "Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity."

1.	NF-kappa B (NF-kB)
2.	DNA (Deoxyribonucleic Acid)
3.	NF-KappaB Inhibitor alpha
4.	jesterone
5.	Transcription Factors (Transcription Factor)
6.	Proteins (Proteins, Gene)
7.	Cysteine (L-Cysteine)