(5- fluoro- 2- methyl- 1- (3,5- dimethoxy- 4- hydroxybenzylidene)- 3- (N- benzyl)indene)acetamide
a microtubule depolymerizing agent that has antineoplastic activity; structure in first source
Also Known As:
OSIP 487703; OSIP-487703; OSIP487703
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Bio-Agent Context: Research Results
|1. ||Neoplasms (Cancer)
|2. ||Colonic Neoplasms (Colon Cancer)
- "Exisulind (sulindac sulfone) and three highly potent derivatives, OSI-461 (CP461), OSIP486823 (CP248), and OSIP487703, inhibit growth and induce apoptosis in SW480 human colon cancer cells, with IC(50)s of 200, 2, 0.1, and 0.003 micromol/L, respectively.
- "The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.
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