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6,6,8- trimethyl- 4,4a,5,6,7,7a,8,9- octahydrocyclopenta(4,5)cyclohepta(1,2- c)- furan- 4,8- diol 4- (N- tert- butoxycarbonyl- 3- phenylisoserinate)

induces autophagy in breast cancer; structure in first source

Also Known As:

AGS 115; AGS-115; AGS115

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        Paclitaxel: 22016
        6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydrocyclopenta(4,5)cyclohepta(1,2-c)-furan-4,8-diol 4-(N-tert-butoxycarbonyl-3-phenylisoserinate): 1
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        Paclitaxel: 22016
        6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydrocyclopenta(4,5)cyclohepta(1,2-c)-furan-4,8-diol 4-(N-tert-butoxycarbonyl-3-phenylisoserinate): 1

Experts

1.	Daniewski, Włodzimierz M: 1 article (08/2005)
2.	Gajkowska, Barbara: 1 article (08/2005)
3.	Godlewski, Michał M: 1 article (08/2005)
4.	Górka, Magdalena: 1 article (08/2005)
5.	Lusakowska, Elzbieta: 1 article (08/2005)
6.	Motyl, Tomasz: 1 article (08/2005)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2005 - "Therefore, AGS 115 and EFDAC appear to be promising candidates for further investigation in anti-cancer therapy."
2.	Breast Neoplasms (Breast Cancer) 08/01/2005 - "The molecular mechanism of cell death induced by AGS 115 and EFDAC, sesquiterpene analogs of paclitaxel, was investigated in human breast cancer MCF-7 cells. " 08/01/2005 - "Autophagy is the dominant type of programmed cell death in breast cancer MCF-7 cells exposed to AGS 115 and EFDAC, new sesquiterpene analogs of paclitaxel."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Sesquiterpenes

Related Therapies and Procedures

1.	Therapeutics