|1.||Uteshev, Victor V: 2 articles (03/2015 - 01/2013)|
|2.||Freitas, Kelen: 2 articles (02/2013 - 01/2013)|
|3.||Bertrand, Daniel: 2 articles (02/2009 - 04/2005)|
|4.||Fernández-Morales, José Carlos: 1 article (05/2015)|
|5.||Guerra-Álvarez, María: 1 article (05/2015)|
|6.||Navarro, Elisa: 1 article (05/2015)|
|7.||Cano-Abad, María F: 1 article (05/2015)|
|8.||López, Manuela G: 1 article (05/2015)|
|9.||Moreno-Ortega, Ana J: 1 article (05/2015)|
|10.||Egea, Javier: 1 article (05/2015)|
|1.||Schizophrenia (Dementia Praecox)
09/01/2012 - "In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors."
04/27/2005 - "Systemic administration of PNU-120596 to rats improved the auditory gating deficit caused by amphetamine, a model proposed to reflect a circuit level disturbance associated with schizophrenia. "
01/01/2015 - "In this article, the author discusses recent findings on α7 nAChR agonists such as DMXB-A, RG3487, TC-5619, tropisetron, EVP-6124 (encenicline), ABT-126, AQW051 and α7 nAChR PAMs such as JNJ-39393406, PNU- 120596 and AVL-3288 (also known as UCI-4083), and their potential as therapeutic drugs for neuropsychiatric diseases, such as schizophrenia. "
06/01/2013 - "Finally, we assessed the interaction between PNU-120596 and nicotine using acute thermal pain, locomotor activity, body temperature and convulsing activity tests in mice. "
02/01/2013 - "Our results indicate that the type II α7 nAChRs PAM PNU-120596, but not the type I α7 nAChRs PAM NS1738, shows significant anti-edematous and anti-allodynic effects in inflammatory and CCI pain models in mice."
01/01/2013 - "Our results indicate that type II α7 nAChR PAM PNU-120596, but not type I α7 nAChR PAM NS1738, shows significant antinociception effects in persistent pain models in mice."
06/01/2013 - "In contrast, PNU-120596 failed to enhance nicotine-induced convulsions, hypomotility and antinociception in acute pain models. "
06/01/2013 - "In this study, we evaluated whether type II α7 positive allosteric modulator PNU-120596 induces antinociception on its own and in combination with choline in the formalin pain model. "
09/01/2012 - "The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat."
09/01/2012 - "Established mechanical hyperalgesia induced by carrageenan or CFA was also partially reversed by compound B and PNU-120596. "
02/01/2013 - "Importantly, PNU-120596 reversed established thermal hyperalgesia and edema induced by carrageenan. "
01/01/2015 - "The present study investigated the effects of α7-nAChRs selective agonists PHA-543613 and type II positive allosteric modulators (PAMs) PNU-120596 in remifentanil induced postoperative hyperalgesia. "
01/01/2015 - "The depression of the increased levels of proinflammatory cytokines and p-NR2B after remifentanil treatment may contribute to the anti-hyperalgesia effects of PHA-543613and PNU-120596 via α7-nAChRs. "
12/01/2011 - "In this study, we demonstrate that inclusion of type II PAMs such as PNU-120596, but not type I, can enable detection of endogenous α7 nAChR-mediated calcium responses in human neuroblastoma (IMR-32) cells. "
05/01/2015 - "Using SH-SY5Y neuroblastoma cells overexpressing α7-nAChRs (α7-SH) and their control (C-SH), we find that PAM of α7-nAChRs with PNU120596: (i) increases inward calcium current (ICa ) and cytosolic Ca(2+) concentration ([Ca(2+) ]cyt ); (ii) releases Ca(2+) from the ER ([Ca(2+) ]ER ) by a Ca(2+) -induced Ca(2+) release mechanism; and (iv) reduces cell viability. "
01/01/2013 - "This study tests the hypothesis that administration of PNU-120596, a type-II positive allosteric modulator (PAM-II) of α7 nicotinic acetylcholine receptors (nAChRs), as long as 6 hours after the onset of focal cerebral ischemia significantly reduces brain injury and neurological deficits in an animal model of ischemic stroke. "
|4.||Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
|5.||Choline (Choline Chloride)
|6.||N- (1- azabicyclo(2.2.2)oct- 3- yl)furo(2,3- c)pyridine- 5- carboxamide