|1.||Xu, Xiao-Ying: 2 articles (06/2015 - 11/2010)|
|2.||Pal, Abhishek: 2 articles (05/2015 - 04/2014)|
|3.||Adhikari, Susanta: 2 articles (05/2015 - 04/2014)|
|4.||Banerjee, Rajkumar: 2 articles (05/2015 - 04/2014)|
|5.||Ghosh, Avijit: 2 articles (05/2015 - 04/2014)|
|6.||Ganguly, Anirban: 2 articles (05/2015 - 04/2014)|
|7.||Yousuf, Md: 2 articles (05/2015 - 04/2014)|
|8.||Nagabhushana, Ananthamurthy: 2 articles (03/2015 - 12/2013)|
|9.||Addlagatta, Anthony: 2 articles (03/2015 - 12/2013)|
|10.||Shaik, Anver Basha: 2 articles (03/2015 - 12/2013)|
11/01/2003 - "To study the antitumor mechanism of 3-substituted aryl oxindole (PH II-7) and determine its effects on cell cycle distribution of tumor cells. "
12/15/2014 - "Synthesis and biological evaluation of novel oxindole-based RTK inhibitors as anti-cancer agents."
12/01/2013 - "A library of imidazopyridine-oxindole conjugates was synthesised and investigated for anticancer activity against various human cancer cell lines. "
01/01/2012 - "Aimed for improved efficacy against resistant cancer cells, we designed and synthesized 25 oxindole derivatives based on indirubin by structure-activity relationship analysis. "
12/15/2014 - "In this study, two series of new heterocyclic compounds containing oxindole scaffold have been designed and synthesized, and their inhibitory activity against the proliferation of nine cancer cell lines has been evaluated. "
01/01/1997 - "Studies on the pharmacological properties of oxindole (2-hydroxyindole) and 5-hydroxyindole: are they involved in hepatic encephalopathy?"
06/20/1998 - "Oxindole in pathogenesis of hepatic encephalopathy."
06/01/2010 - "Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy."
09/01/1999 - "The present findings are in line with the possibility that oxindole may be an additional L-tryptophan-related candidate in the pathogenesis of chronic hepatic encephalopathy."
09/01/1999 - "In the present investigation, we found that oxindole levels were significantly increased in the blood and brain of portacaval-shunted rats, an animal model of chronic hepatic encephalopathy, compared with sham-operated controls. "
|3.||Acute Liver Failure (Fulminant Hepatic Failure)
05/01/1998 - "To study the role that oxindole plays in the neurological symptoms associated with acute liver failure, we measured the changes of its concentration in the brain after massive liver damage, and we investigated the possible metabolic pathways leading to its synthesis. "
05/01/1998 - "Oxindole, a sedative tryptophan metabolite, accumulates in blood and brain of rats with acute hepatic failure."
09/01/1999 - "It has previously been shown that the neurodepressant L-tryptophan metabolite oxindole is increased in the blood and brain of rats with fulminant hepatic failure and in the blood of cirrhotic patients affected by chronic hepatic encephalopathy. "
05/01/1998 - "Rats treated with either thioacetamide (0.2 and 0.4 g/kg i.p., twice) or galactosamine (1 and 2 g/kg i.p.) showed acute liver failure and a large increase in blood or brain oxindole concentrations (from 0.05 +/- 0.01 nmol/g in brains of controls to 1.8 +/- 0.3 nmol/g in brains of thioacetamide-treated animals). "
|4.||Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
10/01/2004 - "When sorted by G1 protein status of T-ALL, p16(+), p15(+) or pRb(-) samples were significantly less sensitive to 3-ATA and TA, but not to oxindole, than p16(-), p15(-) or pRb(+) samples. "
10/01/2004 - "In this study, we tested 3 inhibitors of CDK4, 3-aminothioacridone (3-ATA), thioacridone (TA), and oxindole, for their effects on DNA synthesis and viability in primary T-ALL. "
|5.||Neurodegenerative Diseases (Neurodegenerative Disease)
01/01/2012 - "Notably, IsoRhy-induced autophagy was independent of the mTOR pathway but dependent on the function of Beclin 1. Taken together, data from this study raise the possibility that oxindole alkaloid derivatives may serve as a means to stimulate autophagy in neuronal cells, thereby exerting preventive and therapeutic values against neurodegenerative diseases such as Parkinson disease by reducing pathogenic protein aggregates in neurons."
|9.||DNA (Deoxyribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Chinese Traditional Medicine (Traditional Chinese Medicine)