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AP23846

a highly potent Src family kinase inhibitor; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Adenosine Triphosphate: 27668
        AP23846: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        AP23846: 2
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        AP23846: 2

Experts

1.	Gallick, Gary E: 2 articles (09/2006 - 12/2005)
2.	Metcalf, Chester A: 2 articles (09/2006 - 12/2005)
3.	Sawyer, Tomi K: 2 articles (09/2006 - 12/2005)
4.	Shakespeare, William C: 2 articles (09/2006 - 12/2005)
5.	Trevino, Jose G: 2 articles (09/2006 - 12/2005)
6.	Wang, Yihan: 2 articles (09/2006 - 12/2005)
7.	Coleman, Robert L: 1 article (09/2006)
8.	Dalgarno, David C: 1 article (09/2006)
9.	Gershenson, David M: 1 article (09/2006)
10.	Halder, Jyotsnabaran: 1 article (09/2006)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2006 - "In vivo, Src inhibition by AP23994, an orally bioavailable analogue of AP23846, significantly decreased tumor burden in HeyA8 (P = 0.02), SKOV3ip1 (P = 0.01), as well as HeyA8-MDR (P < 0.03) relative to the untreated controls. " 12/01/2005 - "In this study, we characterize the biological effects of the novel ATP-based Src family kinase inhibitor, AP23846, in tumor cells with high Src activity. "
2.	Adenocarcinoma 12/01/2005 - "Correspondingly, cell culture supernatants from L3.6pl pancreatic adenocarcinoma cells pretreated with AP23846 failed to promote migration of hepatic endothelial cells in vitro and failed to support angiogenesis into gel foams implanted s.c. " 12/01/2005 - "AP23846 reduced cellular migration, vascular endothelial growth factor, and interleukin-8 in a dose-dependent fashion in pancreatic adenocarcinoma cells grown in vitro. "

Related Drugs and Biologics

1.	src-Family Kinases
2.	Adenosine Triphosphate (ATP)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Interleukin-8 (Interleukin 8)