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(2R)- 3- (2- aminomethyl- 2,3- dihydro- 1H- 3a- azacyclopenta(a)inden- 8- yl)- 4- phenylaminopyrrole- 2,5- dione monomethanesulphonate

a protein kinase C-beta isoform selective inhibitor

Also Known As:

JTT-010

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        (2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - (2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - (2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate: 1

Experts

1.	Abe, T: 1 article (09/2005)
2.	Imagawa, N: 1 article (09/2005)
3.	Ito, M: 1 article (09/2005)
4.	Matsushita, M: 1 article (09/2005)
5.	Sagawa, S: 1 article (09/2005)
6.	Sakoda, K: 1 article (09/2005)
7.	Sasase, T: 1 article (09/2005)
8.	Tanaka, M: 1 article (09/2005)
9.	Yamada, H: 1 article (09/2005)

Related Diseases

1.	Hyperalgesia 09/01/2005 - "PKC-beta inhibitor, JTT-010, may be beneficial in suppressing the development of diabetic nerve dysfunction, including hyperalgesia and hypoalgesia."
2.	Diabetic Neuropathies (Diabetic Neuropathy) 09/01/2005 - "In this study, pharmacological effects of a novel PKC-beta isoform selective inhibitor, JTT-010 ((2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate), on diabetic neuropathy were examined. "

Related Drugs and Biologics

1.	Protein Kinase C beta
2.	Protein Isoforms (Isoforms)