|1.||Baird, William M: 2 articles (09/2007 - 09/2002)|
|2.||Penning, Trevor M: 2 articles (03/2007 - 07/2002)|
|3.||Luch, Andreas: 2 articles (06/2004 - 09/2002)|
|4.||Govori, Valbona: 1 article (01/2015)|
|5.||Vllasaliu, Driton: 1 article (01/2015)|
|6.||Shala, Aida: 1 article (01/2015)|
|7.||Norata, Giuseppe Danilo: 1 article (01/2015)|
|8.||Beretta, Giangiacomo: 1 article (01/2015)|
|9.||Krasniqi, Shaip: 1 article (01/2015)|
|10.||Daci, Armond: 1 article (01/2015)|
06/30/2004 - "In consideration of the 100-fold differences in the doses of compounds applied in this study, the tumor-inducing potency increases in the order DBP < 11,12-dihydrodiol < anti-dihydrodiol epoxide. "
03/01/1999 - "Tumor-initiating activity of (-)-(11R,12R)-DB[a,l]P-dihydrodiol, which is the metabolic precursor of the (-)-anti-(11R,12S)-dihydrodiol (13S,14R)-epoxide, was exceptionally higher than the corresponding effect of (+)-(11S,12S)-DB[a,l]P-dihydrodiol, the metabolic precursor of (+)-syn-(11S,12R)-dihydrodiol (13S,14R)-epoxide. "
11/01/1994 - "The tumor-initiating activity of the two diolepoxides in mouse skin was compared to that of DB[a,l]P-11,12-dihydrodiol and the parent DB[a,l]P. "
05/01/1993 - "At 4 nmol DB[a,l]P-11,12-dihydrodiol elicited only benign tumors in 36% of mice. "
07/15/1987 - "The dihydrodiol enantiomers were tested for tumor initiating activity on mouse skin. "
04/01/1996 - "Based on these results, it was concluded that the prevention of the naphthalene cataract probably results from inhibition of the conversion of naphthalene dihydrodiol to 1,2-dihydroxynaphthalene and that the effect of the ARIs cannot be explained by their inhibition of the dihydrodiol dehydrogenase activity of aldose reductase."
01/01/1992 - "In order to study the direct effects of naphthalene metabolites on the lens, we established an in vitro 'naphthalene cataract' model system by exposing rat lens to naphthalene dihydrodiol (2.5 x 10(5) M) containing medium for 48 hr. Under these conditions, we analysed several biochemical parameters including the glutathione level, protein mixed disulfides, protein patterns on SDS-gels, active transport, NA+/K(+)-ATPase activities and the measurement of naphthalene metabolites in the cultured lenses. "
|3.||Dehydration (Water Stress)
07/01/1985 - "Mass spectral analysis of the dehydration products of the oxygen-18-containing trans-dihydrodiol metabolites indicated that 7-Cl-BA 3S,4R-epoxide and 7-Cl-BA 8R,9S-epoxide were the predominant enantiomeric intermediates."
12/01/1998 - "The dihydrodiol undergoes a characteristic acid-catalyzed dehydration to produce phenols. "
04/01/1983 - "Mass spectral analysis of the acid-catalyzed dehydration products of the dihydrodiol indicated that the naphthalene dihydrodiol forms via the addition of water at the C-2 position of naphthalene-1,2-oxide. "
04/15/1979 - "elegans also oxidized dibenzofuran to 2- and 3-hydroxydibenzofuran under conditions that would not lead to the dehydration of the trans-dihydrodiol. "
11/01/1993 - "coli strain expressing the structural genes of naphthalene 1,2-dioxgenase from Pseudomonas sp. NCIB 9816-4. 3-Hydroxycarbazole is presumed to result from the dehydration of an unstable cis-dihydrodiol."
03/01/2007 - "We assessed the effect of benzo[a]pyrene-7,8-dihydrodiol (BPD) on proliferation in p53-null bronchoalveolar carcinoma H358 cells. "
03/01/2007 - "Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells."
07/05/2002 - "Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells."
|5.||Breast Neoplasms (Breast Cancer)
09/28/2007 - "1,4-DFBcPh and its dihydrodiol were subjected to metabolism, and the amount of DNA binding in human breast cancer MCF-7 cells was assessed. "
09/01/2002 - "DNA binding of DB[a,l]P in human mammary carcinoma MCF-7 and human P450-expressing Chinese hamster V79 cell lines was previously shown to occur preferentially with metabolically generated fjord region DB[a,l]P-11,12-dihydrodiol 13,14-epoxides (DB[a,l]PDE). "
|2.||Cytochrome P-450 CYP1A1 (CYP1A1)
|3.||Glutathione (Reduced Glutathione)
|6.||Adenosine Triphosphatases (ATPase)
|9.||DNA (Deoxyribonucleic Acid)
|10.||Epoxy Compounds (Epoxides)