BR96 monoclonal antibody

a chimeric (mouse/human) mAb binding the tumor-associated glycoprotein Lewis Y (Le(Y)

Also Known As:

BR96 mAb; monoclonal antibody BR96

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        BR96 monoclonal antibody: 11
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        BR96 monoclonal antibody: 11
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        BR96 monoclonal antibody: 11

Experts

1.	Nilsson, Rune: 3 articles (08/2014 - 10/2005)
2.	Tennvall, Jan: 3 articles (08/2014 - 10/2005)
3.	Eriksson, Sophie E: 2 articles (08/2014 - 02/2010)
4.	Ohlsson, Tomas: 2 articles (08/2014 - 10/2005)
5.	Mårtensson, Linda: 2 articles (02/2010 - 10/2005)
6.	Sjögren, Hans-Olov: 2 articles (02/2010 - 10/2005)
7.	Bäck, Tom: 1 article (08/2014)
8.	Elgström, Erika: 1 article (08/2014)
9.	Jensen, Holger: 1 article (08/2014)
10.	Lindegren, Sture: 1 article (08/2014)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1999 - "Comparison of 125I- and (111)In-labeled monoclonal antibody BR96 for tumor targeting in combination with extracorporeal immunoadsorption." 03/01/1998 - "7, 144-149] and a tumor-specific chimeric monoclonal antibody, BR96 [Hellstrom, I., et al. (1990) Cancer Res. 50, 2183-2190; Garrigues, J., et al. (1993) Am. J. " 05/01/1994 - "Molecular modeling was used to build a three-dimensional model of the variable regions of the tumor-reactive monoclonal antibody BR96. " 10/01/2005 - "Determining maximal tolerable dose of the monoclonal antibody BR96 labeled with 90Y or 177Lu in rats: establishment of a syngeneic tumor model to evaluate means to improve radioimmunotherapy." 02/15/2010 - "Toxicity-reducing potential of extracorporeal affinity adsorption treatment in combination with the auristatin-conjugated monoclonal antibody BR96 in a syngeneic rat tumor model."
2.	Carcinoma (Carcinomatosis) 08/01/2014 - "Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model." 10/01/1995 - "Monoclonal antibody BR96 recognizes a Le(y)-related carbohydrate antigen expressed on a wide range of carcinomas. "
3.	Adenocarcinoma 05/01/1995 - "Lewis Y antigen as detected by the monoclonal antibody BR96 is expressed strongly in prostatic adenocarcinoma."
4.	Adenocarcinoma of Lung 06/15/1992 - "The antitumor effects of an unmodified murine monoclonal antibody, BR96, were examined in nude mice bearing human lung adenocarcinoma xenografts. "

Related Drugs and Biologics

1.	Antigens
2.	Proteins (Proteins, Gene)
3.	Immunoglobulin G (IgG)
4.	Exotoxins
5.	Recombinant DNA (Recombinant DNA Research)
6.	Carbohydrates
7.	Surface Antigens (Surface Antigen)
8.	auristatin
9.	Lewis Y antigen
10.	BR96 sFv-PE40

Related Therapies and Procedures

1.	Radioimmunotherapy