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5- (5- ethyl- 2- hydroxy- 4- methoxyphenyl)- 4- (4- methoxyphenyl)isoxazole

inhibits Hsp27 phosphorylation; structure in first source

Also Known As:

KRIBB 3; KRIBB-3; KRIBB3

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Novitskii, V V: 2 articles (01/2015 - 11/2012)
2.	Ryazantseva, N V: 2 articles (01/2015 - 11/2012)
3.	Han, Dong Cho: 2 articles (01/2008 - 12/2005)
4.	Kwon, Byoung-Mog: 2 articles (01/2008 - 12/2005)
5.	Shin, Ki Deok: 2 articles (01/2008 - 12/2005)
6.	Son, Kwang-Hee: 2 articles (01/2008 - 12/2005)
7.	Bilen, Cenk Y: 1 article (05/2019)
8.	Dikmen, Asiye Ugras: 1 article (05/2019)
9.	Kiliccioglu, Ilker: 1 article (05/2019)
10.	Konac, Ece: 1 article (05/2019)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/20/2019 - "In the present study, NF-κB inhibitor BAY 11-7082 and/or Hsp-27 inhibitor KRIBB-3 agents were used to investigate the molecular mechanisms mediating androgen receptor expression on prostate cancer cell lines. "
2.	Neoplasms (Cancer) 01/15/2008 - "Furthermore, when KRIBB3 was administered intraperitoneally into nude mice at 50 mg/kg or 100 mg/kg, it inhibited 49.5 or 70.3% of tumor growth, respectively. " 01/15/2008 - "KRIBB3 (5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl) isoxazole) inhibited cancer cell growth in vitro and in vivo. " 01/15/2008 - "KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells." 01/15/2008 - "These results suggest that KRIBB3 is a good drug candidate for cancer therapy." 12/16/2005 - "Overall, our results demonstrate that KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27."

Related Drugs and Biologics

1.	Androgen Receptors (Androgen Receptor)
2.	3- (4- methylphenylsulfonyl)- 2- propenenitrile
3.	Isoxazoles
4.	Small Interfering RNA (siRNA)
5.	Annexin A5
6.	Fluorescein-5-isothiocyanate (FITC)
7.	Protein Kinase C
8.	Propidium (Propidium Iodide)
9.	Heat-Shock Proteins (Heat-Shock Protein)
10.	Glutathione (Reduced Glutathione)

Related Therapies and Procedures

1.	Therapeutics