|1.||Pilc, Andrzej: 2 articles (07/2014 - 04/2012)|
|2.||Li, Xia: 2 articles (03/2013 - 06/2009)|
|3.||Xi, Zheng-Xiong: 2 articles (03/2013 - 06/2009)|
|4.||Dolan, Sharron: 2 articles (09/2011 - 10/2009)|
|5.||Wang, W-Y: 1 article (01/2016)|
|6.||Zhang, H-H: 1 article (01/2016)|
|7.||Xu, W-C: 1 article (01/2016)|
|8.||Zhang, J: 1 article (01/2016)|
|9.||Jia, L-J: 1 article (01/2016)|
|10.||Mao, H: 1 article (01/2016)|
09/01/2014 - "The mGluR 7 stimulation by an agonist AMN082, did not show analgesic effect but induced hyperalgesia in response to thermal nociceptive stimuli."
10/01/2009 - "Intrathecal injection of AMN082 postcarrageenan and postsurgery also significantly attenuated thermal hyperalgesia. "
10/01/2009 - "In the paw incision model, presurgical and postsurgical administration of 1 and 5 mg/kg AMN082 inhibited thermal hyperalgesia, but not allodynia, whereas diclofenac was effective in attenuating both thermal hyperalgesia and allodynia but only when administered postsurgically. "
10/01/2009 - "This study characterized the contribution of metabotropic glutamate receptor 7 (mGlu7 receptor) activation to the development of inflammatory hyperalgesia and allodynia, using a novel, systemically active mGlu7 receptor allosteric agonist, N, N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082). "
10/01/2009 - "Precarrageenan injection of 1 and 5 mg/kg AMN082, but not diclofenac inhibited thermal hyperalgesia, whereas postcarrageenan, both AMN082 and diclofenac attenuated thermal hyperalgesia and allodynia. "
|2.||Memory Disorders (Memory Loss)
|3.||Cocaine-Related Disorders (Cocaine Addiction)
03/01/2013 - "AMN082 or other mGlu7 receptor allosteric agonists may have potential as novel pharmacotherapies for cocaine addiction. "
06/01/2009 - "These data suggest: (1) mGluR7 is critically involved in cocaine's acute reinforcement; (2) GABA-, but not DA-, dependent mechanisms in the ventral striatopallidal pathway appear to underlie AMN082's actions; and (3) AMN082 or other mGluR7-selective agonists may be useful in the treatment of cocaine addiction."
|4.||Schizophrenia (Dementia Praecox)
01/01/2013 - "When given locally, AMN082 also significantly diminished catalepsy in rats; however, its effective striatal doses were 10-fold lower than those used in the SNr (2.5 and 7.5 pmol/0.5 μl/ side vs. 25 and 75 pmol/0.5 μl/side, respectively). "
03/01/2010 - "In addition, AMN082 reduces the duration of haloperidol-induced catalepsy in a mGlu7 receptor-dependent manner in wild-type but not mGlu7 receptor knockout mice. "
03/01/2010 - "Here, we show that oral (5 mg/kg) or intrastriatal administration (0.1 and 0.5 nmol) of AMN082 reverses haloperidol-induced catalepsy in rats. "
01/01/2013 - "We found that AMN082 (1 and 3 mg/kg) decreased the haloperidol (0.25 mg/kg)-induced catalepsy, but was not efficient in attenuating the reserpine (2.5 mg/kg)-induced akinesia. "
01/01/2013 - "The aim of the present study was to determine whether (1) activation of mGluR7 by systemic administration of AMN082 may produce antiparkinsonian-like effects in the haloperidol-induced catalepsy and reserpine-induced akinesia models in rats; (2) striatal and nigral mGluR7 is likely to contribute to such an effect. "
|1.||metabotropic glutamate receptor 7
|3.||Cocaine (Cocaine HCl)
|4.||gamma-Aminobutyric Acid (GABA)
|5.||Diclofenac (SR 38)
|10.||Synapsins (Synapsin I)
|1.||Self Administration (Administration, Self)
|3.||Drug Therapy (Chemotherapy)