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2- (((amino(imino)methyl)amino)carbonyl)- 1- methyl- 4- trifluoromethyl- 1H- indol- 7- yl- hydrogen- sulfate monohydrate

a potent Na+/H+exchange inhibitor

Also Known As:

SM-197378

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 2-(((amino(imino)methyl)amino)carbonyl)-1-methyl-4-trifluoromethyl-1H-indol-7-yl-hydrogen-sulfate monohydrate: 2

Experts

1.	Matsui, Kazuki: 2 articles (10/2005 - 10/2004)
2.	Ohashi, Naohito: 2 articles (10/2005 - 10/2004)
3.	Yamada, Kazuto: 2 articles (10/2005 - 10/2004)
4.	Yamamoto, Setsuko: 2 articles (10/2005 - 10/2004)
5.	Kitano, Masafumi: 1 article (10/2005)
6.	Mori, Masaya: 1 article (10/2005)
7.	Ogawa, Shoji: 1 article (10/2005)
8.	Hotta, Yoshihiro: 1 article (10/2004)
9.	Huang, Lei: 1 article (10/2004)
10.	Ishikawa, Naohisa: 1 article (10/2004)

Related Diseases

1.	Ischemia 10/03/2005 - "With 90 min of ischemia, the anti-necrotic effect of SM-197378 was superior to that of ischemic preconditioning." 10/25/2004 - "The recovery of left ventricular developed pressure (LVDP) from ischemia by reperfusion was 39.0% in the control, while in the hearts pretreated with SM-198110 or SM-197378 (10(-7) M), it was about 100%. " 10/03/2005 - "With 30 and 60 min of ischemia, the anti-necrotic effects of SM-197378 and ischemic preconditioning were similar and superior to that of nicorandil. " 10/03/2005 - "Intravenous administration of SM-197378 before ischemia reduced the infarct size by approximately 30-50% in a dose-dependent manner. " 10/25/2004 - "The protective effects of the Na+-H+ exchange (NHE) inhibitors SM-198110 (2-[[(aminoiminomethyl) amino] carbonyl]-4-chloro-1H-indole-1-propanesulfonic acid monohydrate) and SM-197378 (N-(aminoiminomethyl)-1-methyl-7-(sulfooxy)-4-(trifluoromethyl)-1H-indole-2-carboxamide monohydrate) were investigated in perfused Langendorff guinea-pig hearts subjected to ischemia (40 min) and reperfusion (40 min). "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 10/03/2005 - "The effects of SM-197378, 2-[[[amino(imino)methyl]amino]carbonyl]-1-methyl-4-trifluoromethyl-1H-indol-7-yl=hydrogen=sulfate monohydrate, a novel potent Na+/H+exchange inhibitor, on heart injury were studied using a rabbit model involving 30 min of myocardial ischemia and 5 h of reperfusion. "
3.	Myocardial Infarction 10/03/2005 - "Reduction of myocardial infarct size by SM-197378, a novel Na+/H+ exchange inhibitor, in rabbits."
4.	Infarction (Infarctions) 10/03/2005 - "Moreover, administration of SM-197378 before reperfusion also resulted in a significant, approximately 30-40%, reduction in the infarct size. " 10/03/2005 - "Intravenous administration of SM-197378 before ischemia reduced the infarct size by approximately 30-50% in a dose-dependent manner. "
5.	Heart Injuries 10/03/2005 - "The effects of SM-197378, 2-[[[amino(imino)methyl]amino]carbonyl]-1-methyl-4-trifluoromethyl-1H-indol-7-yl=hydrogen=sulfate monohydrate, a novel potent Na+/H+exchange inhibitor, on heart injury were studied using a rabbit model involving 30 min of myocardial ischemia and 5 h of reperfusion. "

Related Drugs and Biologics

1.	Acids
2.	indole
3.	Nicorandil (SG 75)
4.	Sulfates (Sulfates, Inorganic)
5.	Hydrogen

Related Therapies and Procedures

1.	Intravenous Administration