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4- cyclohexyloxy- 2- (1- (4- (4- methoxy- benzenesulfonyl)piperazin- 1- yl)ethyl)quinazoline

structure in first source

Also Known As:

CFcor-325; VRT-325

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 4-cyclohexyloxy-2-(1-(4-(4-methoxy-benzenesulfonyl)piperazin-1-yl)ethyl)quinazoline: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - 4-cyclohexyloxy-2-(1-(4-(4-methoxy-benzenesulfonyl)piperazin-1-yl)ethyl)quinazoline: 2

Experts

1.	Bilodeau, Claudia: 1 article (06/2015)
2.	Brochiero, Emmanuelle: 1 article (06/2015)
3.	Desrosiers, Martin-Yvon: 1 article (06/2015)
4.	Maillé, Émilie: 1 article (06/2015)
5.	Quintal, Marie-Claude: 1 article (06/2015)
6.	Rousseau, Simon: 1 article (06/2015)
7.	Ruffin, Manon: 1 article (06/2015)
8.	Trinh, Nguyen Thu Ngan: 1 article (06/2015)
9.	Amaral, Margarida D: 1 article (10/2012)
10.	Li, Hongyu: 1 article (10/2012)

Related Diseases

1.	Cysts 10/15/2012 - "Interestingly, treatment of F508del-CFTR cysts with the CFTR corrector VRT-325 and the CFTR corrector-potentiator VRT-532 increased the number, but not size, of F508del-CFTR cysts, possibly because VRT-325 inhibited strongly cell proliferation. "
2.	Cystic Fibrosis (Mucoviscidosis) 06/01/2015 - "We also confirmed a deleterious impact of PsaDM on wt-CFTR currents in non-cystic fibrosis primary airway cells as well as on the rescue of ΔF508-CFTR function induced by VRT-325 in primary cystic fibrosis cells. " 06/01/2015 - "Our aims were, therefore, to evaluate the effect of Pseudomonas aeruginosa on CFTR function and expression in non-cystic fibrosis airway epithelial cells, and to investigate its impact on ΔF508-CFTR rescue by the VRT-325 corrector in cystic fibrosis cells. "

Related Drugs and Biologics

1.	VRT 532