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(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide

a Kv1.5 potassium channel blocker

Also Known As:

DPO-1 compound

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Phosphorus Compounds: 84
  - Phosphines: 18
    - (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide: 1
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Phosphines: 18
    - (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide: 1

Experts

1.	Lynch, Joseph J: 1 article (12/2005)
2.	Regan, Christopher P: 1 article (12/2005)
3.	Stump, Gary L: 1 article (12/2005)
4.	Wallace, Audrey A: 1 article (12/2005)

Related Diseases

1.

Atrial Flutter (Flutter, Atrial)

12/01/2005 - "The antiarrhythmic efficacy of the novel ultrarapid delayed rectifier potassium current (IKur) blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide (DPO-1) was compared with efficacies of the standard class III rapidly activating component of delayed rectifier potassium current (IKr) blockers [+-N-[1'-(6-cyano-1,2,3,4-tetrahydro-2-napthalenyl)-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl] methanesulfonamide hydrochloride (MK499) and ibutilide and the class IC agent propafenone in a canine model of Y-shaped intracaval and right atrial free wall surgical lesions producing the substrate for reentrant atrial flutter. "

Related Drugs and Biologics

1.	Propafenone (Rythmol)
2.	Potassium
3.	Benzopyrans
4.	ibutilide (Corvert)
5.	methanesulfonamide