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cyclic arginine-glycine-aspartic acid peptide

inhibits macrophage infiltration of the kidney and carotid artery lesions in apo-E-deficient mice
Also Known As:
cRGD peptide; cyclic Arg-Gly-Asp peptide; cyclic RGD
Networked: 182 relevant articles (6 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Liu, Shuang: 21 articles (08/2015 - 09/2006)
2. Chen, Xiaoyuan: 17 articles (09/2012 - 01/2004)
3. Kim, Young-Seung: 10 articles (03/2012 - 03/2007)
4. Shi, Jiyun: 8 articles (10/2011 - 12/2008)
5. Zhou, Yang: 7 articles (09/2013 - 01/2011)
6. Wang, Fan: 7 articles (01/2011 - 03/2007)
7. Kataoka, Kazunori: 6 articles (12/2015 - 09/2007)
8. Chakraborty, Sudipta: 6 articles (10/2013 - 08/2009)
9. Matsumoto, Yu: 5 articles (12/2015 - 06/2012)
10. Nishiyama, Nobuhiro: 5 articles (12/2015 - 09/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
03/01/2007 - "Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer."
02/01/2015 - "In this study two (111)In-labeled dimeric cyclic RGD peptides, (111)In(DOTA-Galacto-RGD2) and (111)In(DOTA-3P-RGD2), were evaluated as radiotracers for breast tumor imaging. "
01/01/2011 - "The purpose of this study was the assessment of the feasibility of dynamic positron emission tomography (PET) studies with fluorine-18 fluorodeoxyglucose ((18)F-FDG) to quantify effects of the cyclic Arg-Gly-Asp peptide cilengitide, which targets the ανβ 3 and ανβ 5 integrin receptors in rats with breast cancer bone metastases. "
08/01/2002 - "This study was designed to determine whether, and how, the cyclic Arg-Gly-Asp peptide Cilengitide (EMD 121974), which targets the alpha(v)beta(3) integrin receptor expressed on neovasculature, could increase systemic RIT efficacy of therapy in a human breast cancer tumor model having mutant p53 and expressing bcl-2. "
01/01/2009 - "This report describes the synthesis of two cyclic RGD (Arg-Gly-Asp) conjugates, HYNIC-2PEG(4)-dimer (HYNIC = 6-hydrazinonicotinyl; 2PEG(4)-dimer = E[PEG(4)-c(RGDfK)](2); and PEG(4) = 15-amino-4,7,10,13-tetraoxapentadecanoic acid) and HYNIC-3PEG(4)-dimer (3PEG(4)-dimer = PEG(4)-E[PEG(4)-c(RGDfK)](2)), and evaluation of their (99m)Tc complexes [(99m)Tc(HYNIC-2PEG(4)-dimer)(tricine)(TPPTS)] ((99m)Tc-2PEG(4)-dimer: TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) and [(99m)Tc(HYNIC-3PEG(4)-dimer)(tricine)(TPPTS)] ((99m)Tc-3PEG(4)-dimer) as novel radiotracers for imaging integrin alpha(v)beta(3) expression in athymic nude mice bearing U87MG glioma and MDA-MB-435 breast cancer xenografts. "
3. Neoplasm Metastasis (Metastasis)
4. Atherosclerosis
5. Glioblastoma (Glioblastoma Multiforme)

Related Drugs and Biologics

1. cyclic arginine-glycine-aspartic acid peptide
2. Integrins
3. Cilengitide
4. EMD 121974
5. Integrin beta3 (GPIIIa)
6. Integrin alpha4beta1 (VLA-4)
7. Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
8. Apolipoproteins E (ApoE)
9. Apolipoproteins
10. Antigens

Related Therapies and Procedures

1. Ligation
2. Intravenous Injections
3. Heterologous Transplantation (Xenotransplantation)
4. Quantum Dots (Quantum Dot)
5. Synchrotrons