KR-32568
1
relevant articles (0 outcomes,
0 trials/studies)
found for this Bio-Agent
Description:
Cardioprotective agent; structure in first source
Also Known As:
(5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl)guanidine
Bio-Agent Context: Research Results
Related Diseases
| 1. | Ventricular Tachycardia
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| 2. | Ventricular Fibrillation
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| 3. | Ischemia
12/01/2005
- " In our anesthetized rat model, KR-32568 reduced infarct size from 67 (control) to 43 and 24% at 0.1 and 1.0 mg/kg (i.v. bolus, given 10 min before ischemia), respectively" 12/01/2005
- " KR-32568 at the same doses also significantly reduced the total number of ventricular premature beats during ischemia/reperfusion from 530 (control) to 266 and 115 beats, ventricular tachycardia (VT) incidence from 51 (control) to 21 and 8, VT duration from 238 s (control) to 63 and 33 s, ventricular fibrillation (VF) incidence from 17 (control) to 8 and 0, and VF duration from 85 s to 18 and 1 s" 12/01/2005
- " The effects of a novel sodium/hydrogen exchanger-1 (NHE-1) inhibitor, KR-32568, were studied in an anesthetized rat model of 30 min ischemia/2.5 h reperfusion heart injury"
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| 4. | Heart Injuries
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| 5. | Premature Cardiac Complexes (Extrasystoles)
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| 5 Diseases
and
1
more articles analyzed in the Research Interface, order at left...
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Related Drugs and Biologics
| 1. | Sodium
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| 2. | Hydrogen
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| 2 Drugs and Important Bio-Agents
and
1
more articles analyzed in the Research Interface, order at left...
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