HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2-(3',4',5',6'-tetrahydro-2'H-(2,4') bipyridinyl-1'-yl)-N-m-tolyl-acetamide

structure in first source

Also Known As:

A-412997

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - 2-(3',4',5',6'-tetrahydro-2'H-(2,4') bipyridinyl-1'-yl)-N-m-tolyl-acetamide: 3
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        2-(3',4',5',6'-tetrahydro-2'H-(2,4') bipyridinyl-1'-yl)-N-m-tolyl-acetamide: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2-(3',4',5',6'-tetrahydro-2'H-(2,4') bipyridinyl-1'-yl)-N-m-tolyl-acetamide: 3

Experts

1.	Grayson, Ben: 1 article (04/2015)
2.	Hayward, Andrew: 1 article (04/2015)
3.	Marsh, Samuel: 1 article (04/2015)
4.	Marshall, Kay M: 1 article (04/2015)
5.	Neill, Joanna C: 1 article (04/2015)
6.	Tomlinson, Anneka: 1 article (04/2015)
7.	Deth, Richard: 1 article (11/2014)
8.	Kocsis, Bernat: 1 article (11/2014)
9.	Lee, Peia: 1 article (11/2014)
10.	Brioni, Jorge D: 1 article (09/2005)

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/01/2015 - "A-412997 (1.0µmol/kg) significantly increased vigilance and response inhibition in ADHD-C animals only, with no effect in HA animals. " 04/01/2015 - "Both tolcapone and A-412997 increased vigilance and response inhibition in the ADHD-C subgroup. " 09/01/2005 - "These present studies evaluated the potential cognitive enhancing properties of A-412997 in rat models of ADHD (5-trial repeated acquisition inhibitory avoidance in Spontaneous Hypertensive Rat pups) and short-term memory (Social Recognition), in comparison with the less selective dopamine D4 receptor agonists PD168077 and CP226269. "
2.	Schizophrenia (Dementia Praecox) 11/01/2014 - "Gamma power was assessed before and after subcutaneous injection of a D4R agonist, A-412997, in several doses between 0.3 and 10.0 mg/kg. The experiments were also repeated in a neurodevelopmental model of schizophrenia, in which rats are prenatally treated with methylazoxymethanol (MAM). "

Related Drugs and Biologics

1.	Dopamine D4 Receptors (Dopamine D4 Receptor)
2.	N- ((4- (2- cyanophenyl)- 1- piperazinyl)methyl)- 3- methylbenzamide
3.	Tolcapone (Tasmar)
4.	methylazoxymethanol

Related Therapies and Procedures

1.	Subcutaneous Injections