1- naphthylacetyl- (O- methyl)- tyrosyl- valyl- (O- methyl)- tyrosinal (TP 110)

a 20S proteasome inhibitor with antineoplastic activity; structure in first source

Also Known As:

TP 110; 1-naphthylacetyl-(O-methyl)-L-tyrosyl-L-valyl-(O-methyl)-DL-tyrosinal; TP-110; TP110 compound

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Multiple Myeloma 04/01/2009 - "Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. " 01/01/2010 - "TP-110, a novel proteasome inhibitor, has been found to possess potent growth inhibition in human multiple myeloma cells. " 04/01/2009 - "TP-110, a new proteasome inhibitor, down-regulates IAPs in human multiple myeloma cells."
2.	Prostatic Neoplasms (Prostate Cancer) 04/01/2007 - "A new proteasome inhibitor, TP-110, induces apoptosis in human prostate cancer PC-3 cells." 04/01/2007 - "Recently, we found a new proteasome inhibitor, TP-110, derived from tyropeptin A produced by Kitasatospora sp. Here we report that TP-110 induces apoptosis in human prostate cancer PC-3 cells. "
3.	Leukemia 04/01/2009 - "These results indicate that proteasome inhibitors reduce the level of IAPs and that the apoptosis induced by TP-110 is correlated with the level of IAPs in leukemia cell lines. "