(4- amino- 5- (4- (4- (2,4- dichloro- 3- (2,4- dimethyl- 8- quinolyloxymethyl)phenylsulfonamido)tetrahydro- 2H- 4- pyranoylcarbonyl)piperazino)- 5- oxopentyl)(trimethyl)ammonium
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Description:
MEN-16132 is the (4S)-isomer and chloride, hydrochloride salt; structure in first source
Also Known As:
MEN 16132; MEN-16132; MEN16132
Bio-Agent Context: Research Results
Related Diseases
| 1. | Tics (Tic)
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| 2. | Inflammation
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| 3. | Hypotension (Low Blood Pressure)
11/01/2005
- " At 1 nmol/nostril, MEN16132 activity was significant for at least 6 h with no systemic effect measured as inhibition of BK-induced hypotension, and at 10 nmol/nostril, the inhibitory effect lasted for more than 15 h with only a weak effect on hypotension" 11/01/2005
- " We have tested the activity of 4-(S)-amino-5-(4-[4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl] piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a novel nonpeptide kinin B(2) receptor antagonist, on bradykinin (BK)-induced inflammatory responses, bronchoconstriction, and hypotension in guinea pigs"
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