Forkhead Box Protein O3

A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.

Also Known As:

FOXO3 Protein; Forkhead in Rhabdomyosarcoma-Like 1 Protein; Forkhead in Rhabdomyosarcoma Like 1 Protein; Protein, FOXO3

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Winged-Helix Transcription Factors: 6
      - Forkhead Transcription Factors: 1105
        Forkhead Box Protein O3: 29
  - DNA-Binding Proteins: 2009
    - Winged-Helix Transcription Factors: 6
      - Forkhead Transcription Factors: 1105
        Forkhead Box Protein O3: 29

Xenopus FoxO3 protein

Bio-Agent Context: Research Results