Forkhead Box Protein O1

A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.

Also Known As:

FOXO1 Protein; Forkhead in Rhabdomyosarcoma Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Winged-Helix Transcription Factors: 6
      - Forkhead Transcription Factors: 1105
        Forkhead Box Protein O1: 115
  - DNA-Binding Proteins: 2009
    - Winged-Helix Transcription Factors: 6
      - Forkhead Transcription Factors: 1105
        Forkhead Box Protein O1: 115

Xenopus FoxO1 protein

Bio-Agent Context: Research Results