HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

eurycomanone

from Eurycoma longifolia; structure in first source
Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Orlikova, Barbora: 1 article (01/2014)
2. Hajjouli, Shéhérazade: 1 article (01/2014)
3. Schumacher, Marc: 1 article (01/2014)
4. Chateauvieux, Sébastien: 1 article (01/2014)
5. Dicato, Mario: 1 article (01/2014)
6. Diederich, Marc: 1 article (01/2014)
7. Teiten, Marie-Hélène: 1 article (01/2014)
8. Choo, Chee-Yan: 1 article (01/2014)
9. Wong, Pooi-Fong: 1 article (01/2012)
10. Cheong, Wei-Fun: 1 article (01/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Lung Neoplasms (Lung Cancer)
01/15/2012 - "These findings suggest that eurycomanone at viable therapeutic concentrations of 5-20 μg/ml exhibited significant anti-proliferative and anti-clonogenic cell growth effects on A549 lung cancer cells. "
01/15/2012 - "Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml. The concentration that inhibited 50% of cell growth (GI(50)) was 5.1 μg/ml. The anti-proliferative effects were not fully reversible following the removal of eurycomanone, in which 30% of cell inhibition still remained (p<0.0001, T-test). "
01/15/2012 - "Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells. "
01/15/2012 - "Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28."
01/15/2012 - "Cisplatin, a chemotherapy drug used for the treatment of non small cell lung cancer on the other hand, inhibited A549 cells proliferation at concentrations ranging from 0.2 μg/ml to 15 μg/ml with a GI(50) of 0.58 μg/ml. The treatment with eurycomanone reduced the abundance expression of the lung cancer markers, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, p53 tumor suppressor protein and other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX1) and endoplasmic reticulum protein 28 (ERp28) but not the house keeping genes. "
3. Lymphoid Leukemia
4. Leukemia
5. Inflammation

Related Drugs and Biologics

1. Quassins
2. Heterogeneous-Nuclear Ribonucleoproteins (Informatin)
3. Tumor Suppressor Protein p53
4. Biological Tumor Markers (Tumor Markers)
5. Cisplatin (Platino)
6. heterogeneous nuclear ribonucleoprotein A2-B1
7. eurycomanol
8. prohibitin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)