fludelone

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3 relevant articles (1 outcomes, 1 trials/studies) found for this Bio-Agent

Description: structure in first source

Also Known As:

26-trifluoro-(E)-9,10-dehydro-12,13-desoxy-epothilone

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 40

Polycyclic Compounds: 58

Macrocyclic Compounds: 1

Macrolides: 753

Epothilones: 89

fludelone: 3

Experts

1.	Tong, William P: 1 article (10/2005)
2.	Danishefsky, Samuel J: 1 article (10/2005)
3.	Dong, Huajin: 1 article (10/2005)
4.	Zhang, Xiuguo: 1 article (10/2005)
5.	Chou, Ting-Chao: 1 article (10/2005)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2005 - "The above results indicate that Fludelone is a highly promising compound for cancer chemotherapeutics." 10/15/2005 - "Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route." 09/02/2008 - "In addition, iso-fludelone was shown to exhibit a significant therapeutic effect against an intracranially implanted SK-NAS tumor." 07/26/2005 - "26-Trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B [Fludelone (Flu)] has shown broad antitumor activity in solid tumor models" 10/15/2005 - "Parallel studies with Taxol and Fludelone [20 mg/kg, 6-hour i.v. infusion (q2d x 4) x3] against HCT-116 human colon carcinoma xenografts revealed that both drugs achieved tumor remission; however, all Taxol-treated mice relapsed in approximately 1.3 months, whereas the Fludelone-treated mice were cured without any relapse for over 7 months" Get all the results and reference details, order at left...
2.	Carcinoma (Carcinomatosis) 10/15/2005 - "Parallel studies with Taxol and Fludelone [20 mg/kg, 6-hour i.v. infusion (q2d x 4) x3] against HCT-116 human colon carcinoma xenografts revealed that both drugs achieved tumor remission; however, all Taxol-treated mice relapsed in approximately 1.3 months, whereas the Fludelone-treated mice were cured without any relapse for over 7 months" Get all the results and reference details, order at left...
3.	Leukemia 10/15/2005 - "Furthermore, tumor remission was achieved by Fludelone against SK-OV-3 (ovary), PC-3 (prostate), and the Taxol-resistant CCRF-CEM/Taxol (leukemia) xenograft tumors" Get all the results and reference details, order at left...
4.	Breast Neoplasms (Breast Cancer) 10/15/2005 - "Treatment of nude mice bearing MX-1 human mammary carcinoma xenografts (as large as 3.4% body weight) with Fludelone (6-hour i.v. infusion, 25 mg/kg, q3d x 5, q3d x 4) led to complete disappearance and de facto "cure" (i.e., remission without a relapse for over 15% of the average life span of 2 years)" Get all the results and reference details, order at left...
5.	Body Weight (Weight, Body) 10/15/2005 - "Treatment of nude mice bearing MX-1 human mammary carcinoma xenografts (as large as 3.4% body weight) with Fludelone (6-hour i.v. infusion, 25 mg/kg, q3d x 5, q3d x 4) led to complete disappearance and de facto "cure" (i.e., remission without a relapse for over 15% of the average life span of 2 years)" Get all the results and reference details, order at left...
6 Diseases and 3 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	K 76 carboxylic acid
3.	26- trifluoro- (E)- 9,10- dehydro- 12,13- desoxyepothilone B
4.	nas
4 Drugs and Important Bio-Agents and 3 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
1 Therapies and Procedures and 2 more articles analyzed in the Research Interface, order at left...

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