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valopicitabine

prodrug of 2'-C-methylcytidine; an anti-hepatitis C virus agent; structure in first source

Also Known As:

2'-C-methylcytidine 3'-O-L-valinyl ester; 2'-C-methylcytidine 3'-O-valinyl ester; NM 283; NM-283

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - valopicitabine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - valopicitabine: 2

Experts

1.	Bitetto, Davide: 1 article (02/2007)
2.	Fabris, Carlo: 1 article (02/2007)
3.	Fornasiere, Ezio: 1 article (02/2007)
4.	Pirisi, Mario: 1 article (02/2007)
5.	Rapetti, Rachele: 1 article (02/2007)
6.	Toniutto, Pierluigi: 1 article (02/2007)
7.	Amador, A: 1 article (01/2005)
8.	Benzaria, S: 1 article (01/2005)
9.	Gosselin, G: 1 article (01/2005)
10.	Mathieu, S: 1 article (01/2005)

Related Diseases

1.

02/01/2007 - "Idenix Pharmaceuticals Inc and Novartis AG are codeveloping valopicitabine dihydrochloride, a once-daily oral nucleoside for the potential treatment of HCV infection. "
01/01/2005 - "In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection."

Related Drugs and Biologics

1.	Nucleosides
2.	Esters
3.	Antiviral Agents (Antivirals)