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INCB3344

potent and selective small molecule CCR2 chemokine receptor antagonist

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - INCB3344: 13

Experts

1.	Dansereau, Marc-André: 3 articles (03/2021 - 07/2008)
2.	Sarret, Philippe: 3 articles (03/2021 - 07/2008)
3.	Drummond, Grant R: 3 articles (04/2016 - 11/2012)
4.	Sobey, Christopher G: 3 articles (04/2016 - 11/2012)
5.	Beaudet, Nicolas: 2 articles (03/2021 - 07/2008)
6.	Broughton, Brad R S: 2 articles (04/2016 - 07/2015)
7.	Chu, Hannah X: 2 articles (04/2016 - 07/2015)
8.	Kim, Hyun Ah: 2 articles (04/2016 - 07/2015)
9.	Lee, Seyoung: 2 articles (04/2016 - 07/2015)
10.	Kitabgi, Patrick: 2 articles (04/2011 - 07/2008)

Related Diseases

1.	Pain (Aches) 01/01/2023 - "Further studies revealed that inflammatory pain caused by CFA or incubation of DRG with CCL2 mainly affected Ih currents in small-diameter DRG neurons, which were blocked by co-incubation CCR2 antagonist INCB3344 or adenylate cyclase inhibitor SQ22536. " 07/01/2008 - "These pronociceptive effects of CCL2 are completely prevented by the selective CCR2 antagonist (INCB3344), indicating that CCL2-induced pain facilitation is elicited via direct spinal activation of CCR2 receptor. " 01/01/2021 - "Three different experimental manipulations that reduced the CCR2+ MØ influx also reduced pain behaviors: global CCR2 knockout; systemic injection of INCB3344 (specific CCR2 blocker); and intravenous injection of liposomal clodronate. " 04/13/2011 - "These pathological pain-associated changes in the DHSC were mimicked by the intrathecal injection of exogenous CCL2 in naive rats and were prevented by the administration of INCB3344 or ERK inhibitor (PD98059). "
2.	Hyperalgesia 03/01/2014 - "By contrast, pre-emptive INCB3344 treatment delayed the emergence of trigeminal mechanical allodynia and associated biochemical alterations. " 04/13/2011 - "Finally, mechanical allodynia, which was fully developed 2 weeks after SN-CCI in rats, was attenuated by the intrathecal injection of INCB3344. " 01/01/2018 - "Intense gastric hyperalgesia also developed in DM rats at two weeks after streptozocin administration, which was significantly reduced after intrathecal administration of the CCR2 antagonist INCB3344. "
3.	Ischemia 04/15/2016 - "Previously we showed that INCB3344, a CCR2 antagonist, inhibits transmigration of Ly6C(hi) monocytes into the brain after ischemia-reperfusion. " 07/01/2015 - "Mice were administered either vehicle (dimethyl sulfoxide/carboxymethylcellulose) or INCB3344 (10, 30 or 100 mg/kg IP) 1 hour before ischemia and at 2 and 6 hours after ischemia. " 04/15/2016 - "Mice were administered either vehicle (dimethyl sulfoxide/carboxymethylcellulose) or INCB3344 (30 or 100mg/kg IP) 1h before middle cerebral artery occlusion and at 2 and 6h after the initiation of ischemia. "
4.	Infarction (Infarctions) 04/15/2016 - "INCB3344 had no effect on either neurological deficit or infarct volume. " 07/01/2015 - "Mice treated with INCB3344 exhibited markedly worse functional outcomes and larger infarct volumes, in association with reduced M2 polarization and increased peroxynitrite production in macrophages, compared with vehicle-treated mice. "
5.	Stroke (Strokes) 07/01/2015 - "Ly6C(hi) monocytes were increased 3-fold in the blood and 10-fold in the brain after stroke, and these increases were selectively prevented by INCB3344 in a dose-dependent manner. "

Related Drugs and Biologics

1.	Adenylyl Cyclases (Adenylyl Cyclase)
2.	CCR2 Receptors
3.	Dimethyl Sulfoxide (DMSO)
4.	Carboxymethylcellulose Sodium (Polycell)
5.	Desoxycorticosterone Acetate (DOCA)
6.	Peroxynitrous Acid (Peroxynitrite)
7.	Streptozocin (Streptozotocin)
8.	Salts
9.	Messenger RNA (mRNA)
10.	Clodronic Acid (Clodronate)

Related Therapies and Procedures

1.	Spinal Injections
2.	Intravenous Injections
3.	Treatment Delay