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7-oxozeanol

a TAK1 inhibitor; has anti-inflammatory activity; structure in first source

Also Known As:

5-7-oxo-zeaenol; 5Z-7-oxo-zeaenol; 5Z-7-oxozeanol; 7-oxozeaenol

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Resorcinols: 4
        Zearalenone: 227
        7-oxozeanol: 2
        7-oxozeanol: 2
- Lactones: 1549
  - Zearalenone: 227
    - 7-oxozeanol: 2
  - 7-oxozeanol: 2
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Zearalenone: 227
      - 7-oxozeanol: 2

Experts

1.	Ahmad, Aamir: 1 article (01/2022)
2.	Al Sharie, Ahmed H: 1 article (01/2022)
3.	Al Zu'bi, Yazan O: 1 article (01/2022)
4.	Alali, Feras Q: 1 article (01/2022)
5.	El-Elimat, Tamam: 1 article (01/2022)
6.	Kuttikrishnan, Shilpa: 1 article (01/2022)
7.	Oberlies, Nicholas H: 1 article (01/2022)
8.	Prabhu, Kirti S: 1 article (01/2022)
9.	Uddin, Shahab: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. "
2.	Necrosis 12/01/1999 - "The activity of the natural analogues in the U937 assay varied over 10(4)-fold, with 5Z-7-oxo-zeaenol the most potent of those tested inhibiting tumour necrosis factor-alpha (TNF alpha) production in these cells with IC50 of 6 nM. The isomeric 7-oxo-zeaenol and structurally more distant monorden (radicicol) were the next most active compounds with IC50 approximately 500 nM, and zearalenone, the least active with IC50 > 400 microM. "

Related Drugs and Biologics

1.	Zearalenone
2.	monorden (radicicol)
3.	NF-kappa B (NF-kB)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Phosphotransferases (Kinase)
6.	monocillin II
7.	L 783277
8.	hypothemycin

Related Therapies and Procedures

1.	Therapeutics