1-methyl-1H-indole-2-carboxylic acid (4- (1- (4- (4- acetylpiperazin- 1- yl)cyclohexyl)- 4- amino- 1H- pyrazolo(3,4- d)pyrimidin- 3- yl)- 2- methoxyphenyl)amide
a Lck inhibitor used to prevent heart allograft rejection; structure in first source
Also Known As:
A 770041; A-770041; A770041
Networked: 6
relevant articles (1 outcomes,
1 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Ahmad, Sheikh F:
1 article
(01/2022)
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2. | Al-Harbi, Naif O:
1 article
(01/2022)
|
3. | Alanazi, Ahmed Z:
1 article
(01/2022)
|
4. | Alasmari, Fawaz:
1 article
(01/2022)
|
5. | Alharbi, Metab:
1 article
(01/2022)
|
6. | Alhazzani, Khalid:
1 article
(01/2022)
|
7. | Almutairi, Mohammed:
1 article
(01/2022)
|
8. | Alqahtani, Faleh:
1 article
(01/2022)
|
9. | Alqarni, Saleh A:
1 article
(01/2022)
|
10. | Ibrahim, Khalid E:
1 article
(01/2022)
|
Related Diseases
1. | Asthma (Bronchial Asthma)
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2. | Inflammation (Inflammations)
06/01/2023
- " Our study shows that CE-induced p-LCK levels are concomitant with increased neutrophilic/eosinophilic inflammation and mucus hypersecretion which are significantly mitigated by A770041 treatment. " 08/25/2022
- " Further, the effect of a pharmacological LCK inhibitor, A-770041, on allergic airway inflammation and key intracellular pathways in CD4+ T cells was assessed. " 06/01/2023
- " However, A770041 in combination with dexamethasone caused complete downregulation of mixed granulocytic airway inflammation as well as Th2/Th17 related immune responses. " 01/01/2022
- " Therefore, in this investigation, effect of Lck inhibitor, A-770041 was examined on PLCγ, p38MAPK, NFATc1, NFkB and STAT3, TNF-α, IFN-γ, Foxp3, IL-17A, in CD4+ T cells in imiquimod (IMQ)-induced psoriatic inflammation in mice. "
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3. | Osteosarcoma (Osteogenic Sarcoma)
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4. | Neoplasms (Cancer)
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5. | Fibrosis (Cirrhosis)
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Related Therapies and Procedures