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MLN 944

has both intercalating and antineoplastic activities

Also Known As:

MLN-944; MLN944

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenazines: 42
      - MLN 944: 4

Experts

1.	Charlton, Peter A: 2 articles (10/2005 - 12/2004)
2.	Mistry, Prakash: 2 articles (10/2005 - 10/2004)
3.	Brown, Jeffrey L: 1 article (10/2005)
4.	Harris, Susan M: 1 article (10/2005)
5.	Scott, John A: 1 article (10/2005)
6.	Cree, Ian A: 1 article (12/2004)
7.	Di Nicolantonio, Federica: 1 article (12/2004)
8.	Knight, Louise A: 1 article (12/2004)
9.	Mercer, Stuart J: 1 article (12/2004)
10.	Norris, David: 1 article (12/2004)

Related Diseases

1.

Neoplasms (Cancer)

12/01/2004 - "The ex vivo characterization of XR5944 (MLN944) against a panel of human clinical tumor samples."
10/29/2004 - "The new bisphenazine anticancer drug MLN944 is a novel cytotoxic agent with exceptional anti-tumor activity against a range of human and murine tumor models both in vitro and in vivo. "
01/01/2004 - "Finally, transcriptional profiling analysis of xenograft tumors treated with MLN944 revealed clusters of regulated genes distinct from those observed in irinotecan hydrochloride (CPT-11)-treated tumors. "
01/01/2004 - "MLN944 (XR5944) is a novel bis-phenazine that has demonstrated exceptional efficacy against a number of murine and human tumor models. "
10/01/2005 - "XR5944 (MLN944) is a novel bis-phenazine currently in phase I clinical trials that has demonstrated potent cytotoxic activity against a variety of tumor models. "

Related Drugs and Biologics

1.	XR5944
2.	phenazine
3.	DNA (Deoxyribonucleic Acid)
4.	Cytotoxins (Cytolysins)
5.	Irinotecan (Camptosar)