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12-(3-adamantan-1-ylureido)dodecanoic acid

an antihypertensive agent

Also Known As:

12-(3-adamantan-1-yl-ureido)dodecanoic acid; AUDA cpd

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        12-(3-adamantan-1-ylureido)dodecanoic acid: 5
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        12-(3-adamantan-1-ylureido)dodecanoic acid: 5
Lipids: 114793
- Fatty Acids: 27405
  - Lauric Acids: 8
    - 12-(3-adamantan-1-ylureido)dodecanoic acid: 5

Experts

1.	Bannehr, Marwin: 1 article (01/2019)
2.	Gelep, Julia: 1 article (01/2019)
3.	Gollasch, Maik: 1 article (01/2019)
4.	Haverkamp, Wilhelm: 1 article (01/2019)
5.	Löhr, Lena: 1 article (01/2019)
6.	Schunck, Wolf-Hagen: 1 article (01/2019)
7.	Wutzler, Alexander: 1 article (01/2019)
8.	Chang, Li-Hsin: 1 article (01/2018)
9.	Chen, I-Chih: 1 article (01/2018)
10.	Chen, You-Yin: 1 article (01/2018)

Related Diseases

1.	Cardiomegaly (Heart Hypertrophy) 06/01/2011 - "The sEH inhibitor 12-(3-adamantan-1-yl-ureido)dodecanoic acid administered for 2 weeks starting 5 weeks after surgery in 2K1C mice (25 mg/l in drinking water) reduced aortic pressures and cardiac hypertrophy, improved the coronary relaxations to acetylcholine and restored the inhibitory effect of fluconazole and MSPPOH on acetylcholine-induced relaxations, without modifying the relaxations to NS309 and NS1619. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2018 - "We used a permanent middle cerebral artery occlusion (MCAO) model in adult wild-type mice with the sEH inhibitor 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA) post-treatment and in sEH knockout (sEH KO) mice. " 02/01/2016 - "In this study, we investigated the effects of 14,15-EET and 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), a selective inhibitor of sEH, on multiple elements of neurovascular unit of the rat brain after middle cerebral artery occlusion-induced focal ischemia. "
3.	Ischemia 01/01/2019 - "Ischemia reperfusion experiments were repeated after administration of the sEH-inhibitor 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA). " 02/01/2016 - "In this study, we investigated the effects of 14,15-EET and 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), a selective inhibitor of sEH, on multiple elements of neurovascular unit of the rat brain after middle cerebral artery occlusion-induced focal ischemia. "
4.	Stroke (Strokes) 12/01/2005 - "We hypothesized that 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), a sEH inhibitor, would protect stroke-prone spontaneously hypertensive rats from cerebral ischemia. " 12/01/2005 - "An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats."
5.	Brain Ischemia (Cerebral Ischemia) 12/01/2005 - "We hypothesized that 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), a sEH inhibitor, would protect stroke-prone spontaneously hypertensive rats from cerebral ischemia. "

Related Drugs and Biologics

1.	Drinking Water
2.	Fluconazole (Zonal)
3.	Acetylcholine (Acetylcholine Chloride)
4.	NS 1619
5.	14,15-epoxy-5,8,11-eicosatrienoic acid
6.	Epoxide Hydrolases