(4- methoxy- phenyl)- (6- methoxy- quinazolin- 4- yl)- amine HCl

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3 relevant articles (1 outcomes, 0 trials/studies) found for this Bio-Agent

Description: an excitatory amino acid antagonist

Also Known As:

LY456236

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

2-Ring Heterocyclic Compounds

Quinazolines: 16

(4-methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine HCl: 3

Related Diseases

1.	Pain (Aches) 04/01/2005 - "LY456236 reduced operant responding at 30 mg/kg. CONCLUSION: Both mGluR5 and mGluR1 antagonists are effective in models of pain and anxiety" 04/01/2005 - "METHODS: The mGluR5 antagonists, 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP), and the mGluR1 antagonist, (4-methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine HCl (LY456236), were tested in models of pain [mouse formalin test, rat spinal nerve ligation (SNL)] and anxiety [Vogel conflict, conditioned lick suppression (CLS)], and their efficacious effects were compared to any associated side effects" Get all the results and reference details, order at left...
2.	Seizures (Seizure) 01/01/2005 - "In addition, LY456236 produced a dose-related increase in the stimulus intensity required to produce generalized seizures" 01/01/2005 - "In amygdala-kindled male Sprague-Dawley rats, LY456236 produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity" 01/01/2005 - "In male CF1 mice, LY456236 produced a dose-related inhibition of tonic extensor seizures in the threshold electroshock model, and limbic seizures in the 6-Hz focal seizure model" 01/01/2005 - "In male and female DBA/2 mice, LY456236 produced a dose-related inhibition of sound-induced clonic-tonic seizures" 05/01/2005 - "LY456236 blocked the seizures produced by 30 nmol but not by 400 nmol; dantrolene was ineffective in blocking seizures produced by either dose" Get all the results and reference details, order at left...
3.	Syndrome 05/01/2005 - "The full syndrome, produced by 400 nmol of (S)-3,5-DHPG, was antagonized by the selective mGlu1 receptor antagonist LY456236 but not by the mGlu5 receptor antagonist MPEP or the mGlu2/3 receptor antagonist LY341495" Get all the results and reference details, order at left...
4.	Hyperalgesia 04/01/2005 - "RESULTS: The systemic administration of MPEP, MTEP, and LY456236 reduced hyperalgesia induced by formalin and mechanical allodynia following SNL" Get all the results and reference details, order at left...
5.	Epilepsy (Aura) 01/01/2005 - "Taken together, the present results support the conclusion that mGlu1 receptor antagonists such as LY456236 may have clinical utility in the treatment of epilepsy and other seizure disorders." Get all the results and reference details, order at left...
5 Diseases and 3 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	metabotropic glutamate receptor type 1
2.	metabotropic glutamate receptor 5
3.	(4- methoxy- phenyl)- (6- methoxy- quinazolin- 4- yl)- amine HCl
4.	Formaldehyde (Formol)
5.	Dantrolene (Dantrium)
6.	6-methyl-2-(phenylethynyl)pyridine
7.	LY 341495
8.	pyridine
8 Drugs and Important Bio-Agents and 2 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Ligation
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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