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human shelterin

protein complex formed by six telomere-specific subunits that shapes and safeguards human telomeres; three shelterin subunits, TRF1, TRF2, and POT1 directly recognize TTAGGG repeats; they are interconnected by three additional shelterin proteins, TIN2, TPP1, and Rap1, forming a complex that allows cells to distinguish telomeres from sites of DNA damage
Also Known As:
shelterin, human
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