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ABT-769

has potential for broad-spectrum antiepileptic (anticonvulsant) activity; structure in first source

Also Known As:

(R)-N-(2 amino-2-oxoethyl)spiro(2,5)octane-1-carboxamide

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - ABT-769: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - ABT-769: 1

Experts

1.	Bennani, Youssef: 1 article (09/2005)
2.	Bitner, Robert S: 1 article (09/2005)
3.	Chemburkar, Sanjay R: 1 article (09/2005)
4.	Chen, Jinhua: 1 article (09/2005)
5.	Curzon, Peter: 1 article (09/2005)
6.	Dart, Michael J: 1 article (09/2005)
7.	Decker, Michael W: 1 article (09/2005)
8.	Durmuller, Niklaus: 1 article (09/2005)
9.	Fox, Gerard B: 1 article (09/2005)
10.	Giardina, William J: 1 article (09/2005)

Related Diseases

1.	Seizures (Absence Seizure) 09/01/2005 - "ABT-769 blocked absence-like spike-wave discharge (ED50, 0.15 mmol/kg, p.o.) and shortened the cortical and amygdala afterdischarge duration of kindled seizures (1 and 3 mmol/kg, p.o.). " 09/01/2005 - "ABT-769 was tested for protection against maximal electroshock and pentylenetetrazol-induced seizures in the mouse and for suppression of electrically kindled amygdala seizures and spontaneous absence-like seizures in the rat. " 09/01/2005 - "ABT-769 blocked maximal electroshock, subcutaneous pentylenetetrazol and intravenous pentylenetetrazol-induced seizures with median effective dose (ED50) values of 0.25, 0.38, and 0.11 mmol/kg, p.o., respectively. "
2.	Neural Tube Defects (Exencephaly) 09/01/2005 - "ABT-769 did not affect mitochondrial fatty acid beta-oxidation or induce neural tube defects. "
3.	Epilepsy (Aura) 09/01/2005 - "ABT-769 is an efficacious antiseizure agent in animal models of convulsive and nonconvulsive epilepsy and has a favorable safety profile. "

Related Drugs and Biologics

1.	Pentylenetetrazole (Metrazol)
2.	Fatty Acids (Saturated Fatty Acids)