HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- (4- chlorophenyl)- 4- piperidin- 1- yl- 1,5- dihydroimidazol- 2- one

an anxiolytic agent that is an agonist at the benzodiazepine binding site of the GABA-A receptor

Also Known As:

ELB 139; ELB-139; ELB139; LS-191811

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydroimidazol-2-one: 2
  - Piperidines: 17
    - 1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydroimidazol-2-one: 2

Experts

1.	Löscher, Wolfgang: 1 article (01/2014)
2.	Rundfeldt, Chris: 1 article (01/2014)
3.	Atack, John R: 1 article (05/2005)

Related Diseases

1.	Epilepsy (Aura) 01/01/2014 - "More recently, the imidazolone derivatives imepitoin (ELB138) and ELB139 were shown to act as low-affinity partial agonists at the BZD site of the GABAA receptor, and imepitoin was developed for the treatment of epilepsy. "
2.	Anxiety Disorders (Anxiety Disorder) 05/01/2005 - "The status of these and other BZ site compounds with claimed, but often not explicitly stated, GABA(A) subtype selectivity (such as ELB-139 and ocinaplon) will be reviewed in relation to their development as non-sedating anxiolytics for the treatment of generalised anxiety disorder."

Related Drugs and Biologics

1.	Anti-Anxiety Agents (Anxiolytics)
2.	gamma-Aminobutyric Acid (GABA)
3.	ocinaplon
4.	imidazolone
5.	AWD 131-138