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NVP-SAA164

nonpeptide bradykinin B1 receptor antagonist; structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Bevan, Stuart: 1 article (04/2005)
2.	Burgess, Gillian: 1 article (04/2005)
3.	Colley, Sian: 1 article (04/2005)
4.	Davis, Clare: 1 article (04/2005)
5.	Dragoni, Ilaria: 1 article (04/2005)
6.	Fox, Alyson: 1 article (04/2005)
7.	Kaur, Satbir: 1 article (04/2005)
8.	Li, Bifang: 1 article (04/2005)
9.	McIntyre, Peter: 1 article (04/2005)
10.	Panesar, Moh: 1 article (04/2005)

Related Diseases

1.	Pain (Aches) 04/01/2005 - "These data demonstrate the use of transgenic technology to investigate the in vivo efficacy of species selective agents and show that NVP-SAA164 is a novel orally active B1 receptor antagonist, providing further support for the utility of B1 receptor antagonists in inflammatory pain conditions in man." 04/01/2005 - "We describe the properties of a novel nonpeptide kinin B1 receptor antagonist, NVP-SAA164, and demonstrate its in vivo activity in models of inflammatory pain in transgenic mice expressing the human B1 receptor. " 04/01/2005 - "Oral administration of NVP-SAA164 produced a dose-related reversal of FCA-induced mechanical hyperalgesia and desArg10KD-induced hyperalgesia in hB1-KI mice, but was inactive against inflammatory pain in wild-type mice. "
2.	Hyperalgesia 04/01/2005 - "Oral administration of NVP-SAA164 produced a dose-related reversal of FCA-induced mechanical hyperalgesia and desArg10KD-induced hyperalgesia in hB1-KI mice, but was inactive against inflammatory pain in wild-type mice. "

Related Drugs and Biologics

1.	Kinins

Related Therapies and Procedures

1.	Oral Administration