|1.||Lammertsma, Adriaan A: 6 articles (01/2015 - 04/2005)|
|2.||Windhorst, Albert D: 3 articles (10/2014 - 11/2008)|
|3.||Halldin, Christer: 3 articles (01/2013 - 01/2008)|
|4.||Hillert, Jan: 3 articles (01/2013 - 01/2008)|
|5.||Dierckx, R A: 3 articles (01/2010 - 05/2003)|
|6.||Brooks, David J: 2 articles (09/2015 - 01/2014)|
|7.||Jansen, Gerrit: 2 articles (01/2015 - 01/2013)|
|8.||Weijers, Karin: 2 articles (01/2015 - 01/2013)|
|9.||Gent, Yoony Y J: 2 articles (01/2015 - 01/2013)|
|10.||Molthoff, Carla F M: 2 articles (01/2015 - 01/2013)|
01/01/2013 - "Previously, the potential of imaging (sub)clinical arthritis was demonstrated by targeting the translocator protein in activated macrophages using (R)-[11C]PK11195 and positron emission tomography (PET). "
01/01/2013 - "The novel PET tracer [18F]fluoro-PEG-folate, designed to target FR on activated macrophages provided improved contrast in a rat model of arthritis compared with the accepted macrophage tracer (R)-[11C]PK11195. "
05/01/2003 - "PET visualization of microglia in multiple sclerosis patients using [11C]PK11195."
01/01/2013 - "Recent positron emission tomography (PET) studies using TSPO radioligands such as [11C]PK11195 and [11C]PBR28 have indicated the usefulness of these PET biomarkers in patients with neuroinflammatory diseases, including multiple sclerosis (MS). "
01/15/2008 - "Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients."
09/01/2002 - "Semiquantification of the peripheral-type benzodiazepine ligand [11C]PK11195 in normal human brain and application in multiple sclerosis patients."
04/01/2005 - "The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. "
08/17/2010 - "Imaging of vascular inflammation with [11C]-PK11195 and positron emission tomography/computed tomography angiography."
10/01/2014 - "(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model."
08/17/2010 - "By binding to activated macrophages in the vessel wall, [11C]-PK11195 enables noninvasive imaging of vascular inflammation. "
08/17/2010 - "We sought to investigate whether positron emission tomography/computed tomography (CT) angiography using [11C]-PK11195, a selective ligand for peripheral benzodiazepine receptors expressed in activated macrophages, can be used to image vascular inflammation. "
09/01/2002 - "[11C]PK11195 is a peripheral-benzodiazepine-receptor radioligand used for detection of microglial inflammation. "
09/11/2000 - "In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke."
09/11/2000 - "To investigate the microglial reaction in stroke we used a marker for activated microglia, [11C]PK11195, and PET in five patients with ischemic stroke 5-53 days after infarction. "
02/01/2006 - "In vivo imaging of PBR has been attempted by [11C]PK11195 positron emission tomography (PET), and it has been documented that the [11C]PK11195 binding potential increases in various neurodegenerative disorders such as Alzheimer's disease and stroke. "
01/01/2012 - "A comparative analysis of the two ligands indicates that [11C]vinpocetine shows a number of favourable characteristics over [11C]PK11195, but to demonstrate that it may serve as a prospective molecular imaging biomarker of microglia activation in post-stroke patients, further studies are required."
01/01/2012 - "Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine."
|5.||Parkinson Disease (Parkinson's Disease)
|2.||Biological Markers (Surrogate Marker)
|5.||GABA-A Receptors (GABA(A) Receptor)
|9.||N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamide
|10.||methylated bovine serum albumin (MBSA)