HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2- (1H- indol- 3- yl)- 3- pentylamino- maleimide

structure in first source

Also Known As:

IM-54 cpd

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Xiuping: 1 article (01/2017)
2.	Du, Guanhua: 1 article (01/2017)
3.	Gao, Hongwei: 1 article (01/2017)
4.	Lu, Jin-Jian: 1 article (01/2017)
5.	Sun, Wen: 1 article (01/2017)
6.	Wang, Jinhua: 1 article (01/2017)
7.	Wu, Xiaxia: 1 article (01/2017)
8.	Yu, Jie: 1 article (01/2017)
9.	Zhao, Wenwen: 1 article (01/2017)
10.	Dodo, Kosuke: 1 article (01/2016)

Related Diseases

1.

01/01/2016 - "Modification of our previously reported selective inhibitor of oxidative stress-induced necrosis, 2-(1H-indol-3-yl)-3-pentylamino-maleimide (IM-54) by regioselective reduction of the C-4 carbonyl group afforded a 3-amino-2-indolyllactam (IL-1) with more potent activity. "
01/01/2017 - "This finding was confirmed by experiments showing that MAM-induced cell death was attenuated by the pharmacological or genetic blockage of necroptosis signaling, including RIP1 inhibitor necrostatin-1s (Nec-1s) and siRNA-mediated gene silencing of RIP1 and RIP3, but was unaffected by caspase inhibitor z-vad-fmk or necrosis inhibitor 2-(1H-Indol-3-yl)-3-pentylamino-maleimide (IM54). "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Caspases
3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
4.	3-amino-2-indolyllactam