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KR 31831

an antiangiogenic agent; structure in first source

Also Known As:

KR-31831; KR31831

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - KR 31831: 7
  - Pyrans: 130
    - Benzopyrans: 195
      - KR 31831: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - KR 31831: 7

Experts

1.	Kim, Jae-Hun: 2 articles (11/2012 - 09/2011)
2.	Yang, Jehoon: 2 articles (11/2012 - 09/2011)
3.	Kim, Yung-Jin: 2 articles (06/2008 - 10/2006)
4.	Park, Shi-Young: 2 articles (06/2008 - 10/2006)
5.	Song, Hyun Seok: 2 articles (06/2008 - 10/2006)
6.	Yi, Kyu-Yang: 2 articles (06/2008 - 10/2006)
7.	Lee, Byung Ho: 1 article (02/2022)
8.	Lee, Jeong Hyun: 1 article (02/2022)
9.	Lee, Ju Hee: 1 article (02/2022)
10.	Oh, Kwang-Seok: 1 article (02/2022)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "These results suggest that KR-31831 may have inhibitory effects on tumor angiogenesis through down-regulation of KDR expression." 08/01/2012 - "Evaluation of the angiogenesis inhibitor KR-31831 in SKOV-3 tumor-bearing mice using (64)Cu-DOTA-VEGF(121) and microPET." 10/31/2006 - "Taken together, these results suggest that KR-31831 acts as a novel angiogenesis inhibitor and might be useful for treating hypervascularized cancers." 08/01/2012 - "KR-31831 ((2R,3R,4S)-6-amino-4-[N-(4-chloropheyl)-N-(1H-imidazol-2ylmethyl)amino]-3-hydroxyl-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran), an angiogenesis inhibitor, was evaluated in tumor-bearing mice using molecular imaging technology. "
2.	Choroidal Neovascularization 05/31/2012 - "Anti-angiogenic effect of KR-31831 on corneal and choroidal neovascularization in rat models." 05/31/2012 - "We attempt to determine the effect and mechanism of KR-31831 in rat models of corneal neovascularization and choroidal neovascularization (CNV). "
3.	Corneal Neovascularization 05/31/2012 - "We attempt to determine the effect and mechanism of KR-31831 in rat models of corneal neovascularization and choroidal neovascularization (CNV). " 05/31/2012 - "In the silver nitrate cauterized rat, topical KR-31831 (P = 0.008) or bevacizumab (P = 0.008) reduced effectively the area of corneal neovascularization compared to control on day 14. "
4.	Wounds and Injuries (Trauma) 02/01/2022 - "KR-31831 improves survival and protects hematopoietic cells and radiosensitive tissues against radiation-induced injuries in mice."
5.	Carcinoma (Carcinomatosis) 09/01/2011 - "Our results suggest that DCE-MRI can be a useful tool by which to evaluate the anti-angiogenic effect of KR-31831 on a xenografted human ovarian carcinoma model." 09/01/2011 - "The purpose of this research was to investigate the anti-angiogenic inhibitory effect of KR-31831, a newly developed anti-angiogenic agent, on an in vivo human ovarian carcinoma model using dynamic contrast-enhanced (DCE) MRI. " 09/01/2011 - "Evaluation of antiangiogenic effects of a new synthetic candidate drug KR-31831 on xenografted ovarian carcinoma using dynamic contrast enhanced MRI."

Related Drugs and Biologics

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4.	Benzopyrans
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6.	Bevacizumab (Avastin)
7.	cremophor