RG108

03/01/2018 - "In addition, growth of tumor xenografts from the Eca‑109 cells was significantly inhibited by irradiation in combination with RG108. "
01/01/2014 - "However, additional mechanism might underlie the anti-tumor effects of RG108. "
01/01/2014 - "RG108 is an effective tumor growth suppressor in most PCa cell lines tested. "
03/01/2006 - "Small-molecule inhibitors of DNA methyltransferases such as RG108 represent promising candidates for cancer drug development. "
01/01/2014 - "In this study we aimed to evaluate the anti-cancer properties of RG108, a novel non-nucleoside inhibitor of DNA methyltransferases (DNMT), in PCa cell lines. "

10/01/2021 - "The Impact of EGCG and RG108 on SOCS1 Promoter DNA Methylation and Expression in U937 Leukemia Cells."
10/01/2021 - "Treatment with either EGCG or RG108 reduced SOCS1 promoter methylation and increased SOCS1 expression in U937 cells in a time-dependent manner, which may play a role in leukemia therapy."
12/01/2012 - "In this study, we have observed the antileukemic action of two diverse DNMT inhibitors, the nucleoside agent zebularine and the non-nucleoside agent RG108, in human promyelocytic leukemia (PML) HL-60 cells. "
12/01/2012 - "The results confirmed the utility of zebularine and RG108 in combinations with RA and HDAC inhibitors to reinforce differentiation effects in promyelocytic leukemia."
12/01/2012 - "Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells."

04/24/2023 - "In our research, the ototoxicity of RG108 was investigated in HEI-OC1. "
04/24/2023 - "Our purpose is to probe the incidence of RG108 on cisplatin-induced ototoxicity. "
04/24/2023 - "Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment."
03/01/2022 - "This study aimed to assess the potential effect of the DNA methyltransferase (DNMT) inhibitor RG108 on cisplatin-induced ototoxicity. "

04/24/2023 - "KEGG analysis shows RG108 may act on PI3K-AKT signaling pathway (PASP) in hearing loss. "
03/01/2022 - "In conclusion, RG108 might represent a new potential agent for preventing hearing loss induced by cisplatin via activating the LRP1-PI3K/AKT pathway."

10/01/2018 - "The results showed that the incidence of spontaneous recurrent seizures (SRS) was significantly lower in the RG108 group than the normal saline (NS) group. "
07/11/2017 - "In addition, we demonstrated that RG108 could suppress acute epileptic seizures in KA-treated mice and epileptic discharges in 4-aminopyridine (4-AP)-treated hippocampal slices. "
07/11/2017 - "Here, we further explored the dynamic change (1-day acute period, 10-day latent period and 45-day chronic phase) of DNA methylation and RASgrf1 expression after acute epileptic seizures in kainic acid (KA)-treated mice, and we observed the impact of N-phthalyl-L-tryptophan (RG108), a DNA methyltransferase (DNMT) inhibitor, on an acute epileptic model by polymerase chain reaction (PCR), western blotting, and bisulfite sequencing PCR (BSP). "