oleocanthal

newly pressed extra-virgin olive oil contains oleocanthal, acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen; structure in first source

Also Known As:

Networked: 69 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	El Sayed, Khalid A: 12 articles (05/2021 - 07/2011)
2.	Siddique, Abu Bakar: 10 articles (05/2021 - 01/2017)
3.	Tajmim, Afsana: 5 articles (05/2021 - 01/2019)
4.	Akl, Mohamed R: 5 articles (02/2019 - 01/2014)
5.	Mohyeldin, Mohamed M: 5 articles (02/2019 - 01/2014)
6.	Ayoub, Nehad M: 4 articles (05/2019 - 01/2014)
7.	Gualillo, Oreste: 4 articles (04/2019 - 12/2012)
8.	Lago, Francisca: 4 articles (04/2019 - 12/2012)
9.	Scotece, Morena: 4 articles (04/2019 - 12/2012)
10.	Kaddoumi, Amal: 4 articles (01/2019 - 06/2013)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "The results revealed that treatment with oleocanthal protected against cerebral damage by controlling microglia inflammation through the TLR-4 pathway." 04/23/2021 - "Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice." 05/06/2018 - "Oleocanthal improved clearance of the amyloid beta protein from neurons and reduced the inflammation of astrocytes. " 01/01/2018 - "Oleocanthal (OC), a phenolic compound present in extra virgin olive oil (EVOO), has attracted attention since its discovery for its relevant pharmacological properties in different pathogenic processes, including inflammation. " 07/01/2011 - "Oleocanthal (OLC) is a phenolic component of extra-virgin olive oil, recently supposed to be involved in the modulation of some human diseases, such as inflammation and Alzheimer. "
2.	Neoplasms (Cancer) 12/20/2022 - "Oleocanthal (1) showed the strongest antiproliferative/cytotoxic activity in most cancer cell lines (EC50: 9−20 μM). " 05/18/2021 - "S-(-)-Oleocanthal (OC) leads the bioactive anti-tumor EVOO phenolic ingredients. " 06/11/2020 - "(-)-Oleocanthal (OC) is a naturally occurring phenolic secoiridoid exclusively occurring in EVOO and showed documented anti-breast and other cancer activities via targeting c-MET. " 01/01/2019 - "Our results are especially encouraging since tumor cells often have larger and more numerous lysosomes, making them especially vulnerable to lysosomotropic agents such as oleocanthal." 09/05/2017 - "Treatment with 5mg/kg or 10mg/kg (-)-oleocanthal resulted in 97% inhibition of tumor growth in orthotopic athymic mice bearing BT-474 tumor xenografts compared to vehicle-treated animals. "
3.	Alzheimer Disease (Alzheimer's Disease) 07/23/2023 - "Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease." 01/27/2023 - "Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer's Disease." 05/18/2021 - "(-)-Oleocanthal Nutraceuticals for Alzheimer's Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model." 01/01/2019 - "(-)-Oleocanthal (OC) and other EVOO phenolics gain progressive research attention due to their documented biological effects against cancer, inflammations, and Alzheimer's disease. " 01/01/2020 - "Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing."
4.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "The aim of this study was to characterize the intracellular mechanisms involved in mediating the anticancer effects of (-)-oleocanthal treatment and the potential involvement of c-Met receptor signaling components in breast cancer. " 05/18/2021 - "Comparative Gene Signature of (-)-Oleocanthal Formulation Treatments in Heterogeneous Triple Negative Breast Tumor Models: Oncological Therapeutic Target Insights." 10/05/2019 - "Optimization of Taste-Masked (-)-Oleocanthal Effervescent Formulation with Potent Breast Cancer Progression and Recurrence Suppressive Activities." 11/01/2015 - "Oleocanthal treatment caused a marked downregulation of phosphorylated mTOR in metastatic breast cancer cell line (MDA-MB-231). " 11/01/2015 - "Subsequent experimental validation indicated that oleocanthal indeed inhibited the enzymatic activity of mTOR with an IC50 value of 708 nM. Oleocanthal inhibits the growth of several breast cancer cell lines at low micromolar concentration in a dose-dependent manner. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 04/01/2015 - "Among these phenolic constituents, oleocanthal has recently emerged as a potential therapeutic molecule for different diseases, showing relevant pharmacological properties in various pathogenic processes, including inflammation, cancers and neurodegenerative diseases. " 10/05/2019 - "S-(-)-Oleocanthal (OC), a naturally occurring phenolic secoiridoid exclusively found in extra-virgin olive oil (EVOO), is a potential nutraceutical therapeutic for inflammation, neurodegenerative diseases, and many malignancies, especially breast cancer (BC). " 06/19/2013 - "Oleocanthal, a phenolic component of extra-virgin olive oil, has been recently linked to reduced risk of Alzheimer's disease (AD), a neurodegenerative disease that is characterized by accumulation of β-amyloid (Aβ) and tau proteins in the brain. "

Related Drugs and Biologics

1.	Olive Oil
2.	oleacein
3.	Amyloid beta-Peptides
4.	Polyphenols
5.	Amyloid (Amyloid Fibrils)
6.	4-hydroxyphenylethanol
7.	oleuropein aglycone
8.	Proteins (Proteins, Gene)
9.	oleuropein
10.	Iridoids

Related Therapies and Procedures

1.	Mediterranean Diet
2.	Plant-Based Diet
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Castration