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6'-guanidinonaltrindole

a tissue-selective analgesic; structure in first source

Also Known As:

6'-GNTI

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Burtscher, Johannes: 1 article (01/2016)
2.	Colmers, William F: 1 article (01/2016)
3.	MacKay, James P: 1 article (01/2016)
4.	Schwarzer, Christoph: 1 article (01/2016)
5.	Zangrandi, Luca: 1 article (01/2016)
6.	Berg, Kelly A: 1 article (02/2012)
7.	Clarke, William P: 1 article (02/2012)
8.	Devi, Lakshmi A: 1 article (02/2012)
9.	Gomes, Ivone: 1 article (02/2012)
10.	Gupta, Achla: 1 article (02/2012)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/2016 - "As previously shown for U-50488H, 6'-GNTI markedly increased the threshold for pentylenetetrazole-induced seizures. " 01/01/2016 - "We investigated the effects of the κ receptor agonist U-50488H and the G-protein biased partial κ receptor agonist 6'-GNTI in models of acute seizures and drug-resistant temporal lobe epilepsy and in the conditioned place avoidance (CPA) test. "
2.	Hyperalgesia 02/01/2012 - "Evidence for DOR-KOR heteromers in peripheral sensory neurons included coimmunoprecipitation of DOR with KOR, a DOR-KOR heteromer selective antibody augmented the antinociceptive effect of DPDPE in vivo, and the DOR-KOR heteromer agonist 6'-GNTI inhibited adenylyl cyclase activity in vitro as well as PGE(2)-stimulated thermal allodynia in vivo. "
3.	Temporal Lobe Epilepsy 01/01/2016 - "We investigated the effects of the κ receptor agonist U-50488H and the G-protein biased partial κ receptor agonist 6'-GNTI in models of acute seizures and drug-resistant temporal lobe epilepsy and in the conditioned place avoidance (CPA) test. "

Related Drugs and Biologics

1.	D-Penicillamine (2,5)- Enkephalin
2.	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
3.	GTP-Binding Proteins (G-Protein)
4.	Pentylenetetrazole (Metrazol)
5.	Adenylyl Cyclases (Adenylyl Cyclase)